Gudgeon A C, Hindmarch I
Br J Clin Pharmacol. 1983;16 Suppl 1(Suppl 1):121S-126S. doi: 10.1111/j.1365-2125.1983.tb02282.x.
Twelve healthy volunteers each received acute doses of placebo and 5, 10, 15 and 20 mg of midazolam. Seven subjects were tested before and 1, 4 and 7 h after treatment. Five subjects were given the same five treatments nocturnally and tested the following morning, 10-12 h after treatment. Tests on various measures of sedation (choice reaction time and critical flicker fusion) and of drowsiness (line analogue rating scales) showed midazolam at 15 and 20 mg dose levels to be a potent sedative agent. The present results suggest that the activity of midazolam is at a maximum 1 h after ingestion and that the effects of the drug have dissipated 7 h after treatment.
12名健康志愿者每人分别接受了安慰剂以及5毫克、10毫克、15毫克和20毫克咪达唑仑的急性剂量。7名受试者在治疗前以及治疗后1小时、4小时和7小时接受测试。5名受试者在夜间接受相同的五种治疗，并在治疗后10 - 12小时的次日早晨接受测试。对各种镇静指标（选择反应时间和临界闪烁融合）以及嗜睡指标（视觉类比评分量表）的测试表明，15毫克和20毫克剂量水平的咪达唑仑是一种强效镇静剂。目前的结果表明，咪达唑仑的活性在摄入后1小时达到最大值，并且该药物的作用在治疗后7小时已消散。
