Loeffler K U, Jay J L
Department of Pathology, University of Glasgow.
Br J Ophthalmol. 1988 Jan;72(1):29-35. doi: 10.1136/bjo.72.1.29.
The tissue reaction to a functioning Molteno implant has been studied by light microscopy and by scanning and transmission electron microscopy. The material was obtained from an aphakic 83-year-old human eye which required enucleation because of intractable bullous keratopathy, despite well controlled intraocular pressure. The tissue response around the silicone rubber tube was that of simple fibroblastic activity. Around the implant, however, there was fibrous tissue in which necrotic cell debris was prominent. No significant inflammation was observed in this tissue, but the choroid beneath the implant showed a focal inflammatory cell infiltrate. The morphology suggests that the tissue around all surfaces of the implant (450 mm2) is exposed to aqueous, which seems to have a toxic effect on the encapsulating connective tissue. The changes seen in the tissue exposed to draining aqueous are similar to those described in experimental studies of the effect of aqueous on cell growth in tissue culture.
通过光学显微镜、扫描电子显微镜和透射电子显微镜对运行中的莫尔滕诺植入物的组织反应进行了研究。材料取自一名83岁无晶状体人眼，尽管眼压控制良好，但因顽固性大泡性角膜病变而需要摘除眼球。硅橡胶管周围的组织反应为单纯的成纤维细胞活动。然而，植入物周围有纤维组织，其中坏死细胞碎片突出。该组织中未观察到明显炎症，但植入物下方的脉络膜有局灶性炎性细胞浸润。形态学表明，植入物所有表面（450平方毫米）周围的组织都暴露于房水中，这似乎对包裹性结缔组织有毒性作用。在暴露于引流房水的组织中看到的变化与在组织培养中关于房水对细胞生长影响的实验研究中描述的变化相似。
