Department of Anesthesiology, Kansai Medical University, Osaka, Japan.
Immunopharmacol Immunotoxicol. 2021 Feb;43(1):100-104. doi: 10.1080/08923973.2020.1869256. Epub 2021 Jan 11.
2,6-Di-isopropylphenol (propofol) is an intravenous general anesthetic widely used in the operating room for general anesthesia and in the intensive care unit for sedation. The mouse air pouch model is versatile in studying the anti-inflammatory effect of a drug on a local inflammation, which is induced by a variety of substances. In this study, using the carrageenan-induced air pouch inflammation model, we tested whether propofol mitigates inflammation occurring locally in the mouse air pouch. Carrageenan-induced air pouch inflammation model. Propofol inhibited the production of tumor necrosis factor (TNF)-α and interleukin (IL)-6 in the pouch. Propofol also inhibited the production of neutrophil chemokines, KC and MIP-2, and decreased the number of both Ly-6G/CD11b cells (assumed to be primarily neutrophils) and Ly-6G/CD11b cells (assumed to be monocytes/macrophages), recruited into the pouch at 3 h after injection of carrageenan. Propofol has an anti-inflammatory property in the carrageenan-induced mouse air pouch local inflammation model, by inhibiting the production of pro-inflammatory cytokines (TNF-α and IL-6), as well as by inhibiting the production of chemokines (KC and MIP-2), which might be associated with the inhibition of intra-pouch recruitment of white blood cells.
2,6-二异丙基苯酚（丙泊酚）是一种广泛应用于手术室全身麻醉和重症监护病房镇静的静脉内全身麻醉剂。在研究药物对局部炎症的抗炎作用方面，鼠气囊模型具有多功能性，这种炎症是由各种物质引起的。在这项研究中，我们使用角叉菜胶诱导的气囊炎症模型，测试了丙泊酚是否能减轻小鼠气囊局部发生的炎症。角叉菜胶诱导的气囊炎症模型。丙泊酚抑制了囊中肿瘤坏死因子 (TNF)-α 和白细胞介素 (IL)-6 的产生。丙泊酚还抑制了中性粒细胞趋化因子 KC 和 MIP-2 的产生，并减少了在注射角叉菜胶后 3 小时招募到囊中 Ly-6G/CD11b 细胞（假定为主要是中性粒细胞）和 Ly-6G/CD11b 细胞（假定为单核细胞/巨噬细胞）的数量。丙泊酚在角叉菜胶诱导的小鼠气囊局部炎症模型中具有抗炎特性，通过抑制促炎细胞因子（TNF-α 和 IL-6）的产生，以及抑制趋化因子（KC 和 MIP-2）的产生，这可能与抑制白细胞在气囊内的募集有关。
