Yi Shuyuan, Tao Xinyi, Wang Yin, Cao Qianqian, Zhou Zhixia, Wang Shoushi
School of Anesthesiology, Weifang Medical University, Weifang, China.
Institute for Translational Medicine, The Affiliated Hospital of Qingdao University, College of Medicine, Qingdao University, Qingdao, China.
Front Pharmacol. 2022 Aug 17;13:964771. doi: 10.3389/fphar.2022.964771. eCollection 2022.
Macrophages work with monocytes and dendritic cells to form a monocyte immune system, which constitutes a powerful cornerstone of the immune system with their powerful antigen presentation and phagocytosis. Macrophages play an essential role in infection, inflammation, tumors and other pathological conditions, but these cells also have non-immune functions, such as regulating lipid metabolism and maintaining homeostasis. Propofol is a commonly used intravenous anesthetic in the clinic. Propofol has sedative, hypnotic, anti-inflammatory and anti-oxidation effects, and it participates in the body's immunity. The regulation of propofol on immune cells, especially macrophages, has a profound effect on the occurrence and development of human diseases. We summarized the effects of propofol on macrophage migration, recruitment, differentiation, polarization, and pyroptosis, and the regulation of these propofol-regulated macrophage functions in inflammation, infection, tumor, and organ reperfusion injury. The influence of propofol on pathology and prognosis via macrophage regulation is also discussed. A better understanding of the effects of propofol on macrophage activation and function in human diseases will provide a new strategy for the application of clinical narcotic drugs and the treatment of diseases.
巨噬细胞与单核细胞和树突状细胞共同作用形成单核细胞免疫系统，凭借其强大的抗原呈递和吞噬作用，构成了免疫系统的强大基石。巨噬细胞在感染、炎症、肿瘤及其他病理状况中发挥着至关重要的作用，但这些细胞也具有非免疫功能，如调节脂质代谢和维持体内稳态。丙泊酚是临床常用的静脉麻醉药。丙泊酚具有镇静、催眠、抗炎和抗氧化作用，且参与机体免疫。丙泊酚对免疫细胞尤其是巨噬细胞的调节，对人类疾病的发生发展具有深远影响。我们总结了丙泊酚对巨噬细胞迁移、募集、分化、极化和焦亡的影响，以及这些丙泊酚调节的巨噬细胞功能在炎症、感染、肿瘤和器官再灌注损伤中的调节作用。还讨论了丙泊酚通过巨噬细胞调节对病理和预后的影响。更好地了解丙泊酚对人类疾病中巨噬细胞活化和功能的影响，将为临床麻醉药物的应用和疾病治疗提供新策略。
