Department of Pharmacology and Toxicology and Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, Indiana.
Kansas Intellectual and Developmental Disabilities Research Center (KIDDRC), Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas.
Curr Protoc. 2021 Aug;1(8):e183. doi: 10.1002/cpz1.183.
The subcutaneous air pouch is an in vivo model that can be used to study the components of acute and chronic inflammation, the resolution of the inflammatory response, the oxidative stress response, and potential therapeutic targets for treating inflammation. Injection of irritants into an air pouch in rats or mice induces an inflammatory response that can be quantified by the volume of exudate produced, the infiltration of cells, and the release of inflammatory mediators. The model presented in this article has been extensively used to identify potential anti-inflammatory drugs. © 2021 Wiley Periodicals LLC. Basic Protocol: Air pouch model in the rat Alternate Protocol: Air pouch model in the mouse.
皮下气囊是一种体内模型，可用于研究急性和慢性炎症的成分、炎症反应的消退、氧化应激反应以及治疗炎症的潜在治疗靶点。向大鼠或小鼠的气囊中注射刺激性物质会引发炎症反应，可通过产生的渗出物体积、细胞浸润和炎症介质的释放来定量。本文介绍的模型已被广泛用于鉴定潜在的抗炎药物。© 2021Wiley Periodicals LLC. 基本方案：大鼠气囊模型 可选方案：小鼠气囊模型。
