Chen Shuang, Chen Yongmin, Zhang Yukang, Kuang Xi, Liu Yan, Guo Meiwen, Ma Lin, Zhang Daqi, Li Qifu
Department of Neurology, The First Affiliated Hospital of Hainan Medical University, Haikou, China.
Key Laboratory of Brain Science Research and Transformation in Tropical Environment of Hainan Province, Hainan Medical University, Haikou, China.
Front Neurosci. 2020 Dec 8;14:601193. doi: 10.3389/fnins.2020.601193. eCollection 2020.
Epilepsy is a disease characterized by recurrent, episodic, and transient central nervous system (CNS) dysfunction resulting from an excessive synchronous discharge of brain neurons. It is characterized by diverse etiology, complex pathogenesis, and difficult treatment. In addition, most epileptic patients exhibit social cognitive impairment and psychological impairment. Iron is an essential trace element for human growth and development and is also involved in a variety of redox reactions in organisms. However, abnormal iron metabolism is associated with several neurological disorders, including hemorrhagic post-stroke epilepsy and post-traumatic epilepsy (PTE). Moreover, ferroptosis is also considered a new form of regulation of cell death, which is attributed to severe lipid peroxidation caused by the production of reactive oxygen species (ROS) and iron overload found in various neurological diseases, including epilepsy. Therefore, this review summarizes the study on iron metabolism and ferroptosis in epilepsy, in order to elucidate the correlation between iron and epilepsy. It also provides a novel method for the treatment, prevention, and research of epilepsy, to control epileptic seizures and reduce nerve injury after the epileptic seizure.
癫痫是一种以脑神经元过度同步放电导致反复、发作性和短暂性中枢神经系统（CNS）功能障碍为特征的疾病。其特点是病因多样、发病机制复杂且治疗困难。此外，大多数癫痫患者存在社会认知障碍和心理障碍。铁是人体生长发育必需的微量元素，也参与生物体的多种氧化还原反应。然而，铁代谢异常与多种神经系统疾病有关，包括出血性中风后癫痫和创伤后癫痫（PTE）。此外，铁死亡也被认为是一种新的细胞死亡调节形式，它归因于各种神经系统疾病（包括癫痫）中活性氧（ROS）产生和铁过载导致的严重脂质过氧化。因此，本综述总结了癫痫中铁代谢和铁死亡的研究，以阐明铁与癫痫之间的相关性。它还为癫痫的治疗、预防和研究提供了一种新方法，以控制癫痫发作并减少癫痫发作后的神经损伤。
