Mo Xiao, Meng Qianqian, Yang Xinjian, Li Haiyun
Beijing Key Laboratory of Fundamental Research on Biomechanics in Clinical Application, School of Biomedical Engineering, Capital Medical University, Beijing, China.
Beijing Neurosurgical Institute, Beijing Tiantan Hospital, Beijing, China.
Front Neurol. 2020 Dec 23;11:534096. doi: 10.3389/fneur.2020.534096. eCollection 2020.
The inflow angle of intracranial aneurysms (IAs) can impact the hemodynamics of IAs, therefore it is likely to contribute to IA clinical rupture risk stratification. This study aimed to assess the effect of inflow angle on the hemodynamics of IAs, as well as its potential ability to predict IA rupture risk. A novel algorithm was developed to build a series of inflow angle models on patient-specific IA models, which were reconstructed from IA 3DRA image data of eleven clinical patients. Fully coupled fluid-structure interaction (FSI) simulations were performed to quantify hemodynamic characteristics of the established IA models with various inflow angles. Hemodynamic parameters including wall shear stress (WSS), flow velocity, flow pattern, inflow zone, impingement region, pressure, and energy loss (EL) were calculated and analyzed. It was demonstrated from the analysis that a rise in the IA inflow angle is associated with the following hemodynamic changes: more direct blood flowed into the aneurysm sac, higher velocity at the upside of the aneurysm, upregulated flow velocity and WSS in the aneurysm, more complicated flow patterns, extended inflow zone, the impingement region moving upward from the neck to the apex of the aneurysm, and higher WSS and larger flow velocity at the inflow zone of the IAs. Therefore, the proposed method may be helpful in exploring the hemodynamic variations of IAs with inflow angles. The findings could be conducive to hemodynamic studies on the association between IA inflow angle and its rupture risk.
颅内动脉瘤（IA）的流入角度会影响其血流动力学，因此可能有助于IA临床破裂风险分层。本研究旨在评估流入角度对IA血流动力学的影响，以及其预测IA破裂风险的潜在能力。开发了一种新算法，在患者特异性IA模型上构建一系列流入角度模型，这些模型由11例临床患者的IA 3DRA图像数据重建而成。进行了全耦合流固相互作用（FSI）模拟，以量化具有不同流入角度的已建立IA模型的血流动力学特征。计算并分析了包括壁面剪应力（WSS）、流速、流型、流入区、撞击区域、压力和能量损失（EL）在内的血流动力学参数。分析表明，IA流入角度的增加与以下血流动力学变化相关：更多的血液直接流入动脉瘤囊，动脉瘤上方的流速更高，动脉瘤内的流速和WSS上调，流型更复杂，流入区扩大，撞击区域从动脉瘤颈部向上移动到顶端，IA流入区的WSS更高且流速更大。因此，所提出的方法可能有助于探索具有不同流入角度的IA的血流动力学变化。这些发现可能有助于对IA流入角度与其破裂风险之间关联的血流动力学研究。
