Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.
Front Endocrinol (Lausanne). 2020 Dec 23;11:572089. doi: 10.3389/fendo.2020.572089. eCollection 2020.
The complex functions of adipose tissue have been a focus of research interest over the past twenty years. Adipose tissue is not only the main energy storage depot, but also one of the largest endocrine organs in the body and carries out crucial metabolic functions. Moreover, brown and beige adipose depots are major sites of energy expenditure through the activation of adaptive, non-shivering thermogenesis. In recent years, numerous signaling molecules and pathways have emerged as critical regulators of adipose tissue, in both homeostasis and obesity-related disease. Among the best characterized are members of the p38 kinase family. The activity of these kinases has emerged as a key contributor to the biology of the white and brown adipose tissues, and their modulation could provide new therapeutic approaches against obesity. Here, we give an overview of the roles of the distinct p38 family members in adipose tissue, focusing on their actions in adipogenesis, thermogenic activity, and secretory function.
在过去的二十年中，脂肪组织的复杂功能一直是研究的重点。脂肪组织不仅是主要的能量储存库，还是人体最大的内分泌器官之一，发挥着至关重要的代谢功能。此外，棕色和米色脂肪组织通过激活适应性、非颤抖性产热，是能量消耗的主要部位。近年来，许多信号分子和途径已成为脂肪组织在稳态和肥胖相关疾病中关键的调节因子。其中，p38 激酶家族成员最为突出。这些激酶的活性已成为白色和棕色脂肪组织生物学的关键贡献者，其调节可能为肥胖症提供新的治疗方法。在这里，我们概述了不同 p38 家族成员在脂肪组织中的作用，重点介绍它们在脂肪生成、产热活性和分泌功能中的作用。
