Xie Junkai, Wettschurack Kyle, Yuan Chongli
Davidson School of Chemical Engineering, Purdue University, West Lafayette, IN, United States.
Purdue University Center for Cancer Research, Purdue University, West Lafayette, IN, United States.
Front Genet. 2020 Dec 23;11:623117. doi: 10.3389/fgene.2020.623117. eCollection 2020.
Developmental toxicity and its affiliation to long-term health, particularly neurodegenerative disease (ND) has attracted significant attentions in recent years. There is, however, a significant gap in current models to track longitudinal changes arising from developmental toxicity. The advent of induced pluripotent stem cell (iPSC) derived neuronal culture has allowed for more complex and functionally active neuronal models. Coupled with recent progress in the detection of ND biomarkers, we are equipped with promising new tools to understand neurotoxicity arising from developmental exposure. This review provides a brief overview of current progress in neuronal culture derived from iPSC and in ND markers.
发育毒性及其与长期健康，特别是神经退行性疾病（ND）的关联近年来引起了广泛关注。然而，目前用于追踪发育毒性引起的纵向变化的模型存在重大差距。诱导多能干细胞（iPSC）衍生的神经元培养技术的出现，使得构建更复杂且功能活跃的神经元模型成为可能。再加上近期在ND生物标志物检测方面的进展，我们拥有了很有前景的新工具来理解发育暴露引起的神经毒性。本文综述简要概述了iPSC衍生神经元培养和ND标志物的当前进展。
