新冠病毒肺炎患者与对照组的中性粒细胞与淋巴细胞比值及血小板与淋巴细胞比值及其与疾病预后的关系
Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios in COVID-19 Patients and Control Group and Relationship with Disease Prognosis.
作者信息
Eslamijouybari Mohammad, Heydari Keyvan, Maleki Iradj, Moosazadeh Mahmood, Hedayatizadeh-Omran Akbar, Vahedi Lale, Ghasemian Roya, Sharifpour Ali, Alizadeh-Navaei Reza
机构信息
Gastrointestinal Cancer Research Center, Non-Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran.
Student Research Committee, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
出版信息
Caspian J Intern Med. 2020 Fall;11(Suppl 1):531-535. doi: 10.22088/cjim.11.0.531.
BACKGROUND
The present study aimed to compare the complete blood count (CBC) indices between COVID-19 patients and the control group, and assess the relationship of these indices with COVID-19 prognosis.
METHODS
COVID-19 patients (confirmed by PCR or CT-Scan) who visited Imam Hospital in Sari were selected in this case-control study. The control group was selected from Tabari cohort population matched with the case group in terms of gender and age. CBC, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and outcome of the disease (in the case group) were assessed in this study.
RESULTS
The number of participants were 527 in both case and control groups, of which, 232 (44%) were females in each arms. Platelet count, lymphocyte count, and hemoglobin concentration were also higher in the control group (P=0.000). NLR and PLR were significantly higher in COVID-19 patients compared to the control group (P=0.000). NLR had a significant relationship with the severity of the disease. NLR was two times higher in the patients who died of COVID-19 than those who recovered (P=0.000). ROC curve analysis for diagnostic values of NLR and PLR showed that the areas under the ROC curves for NLR and PLR were 0.703 (95% CI: 0.64-0.76) and 0.535 (95% CI: 0.46-06), respectively.
CONCLUSION
NLR can be used as a prognostic marker for COVID-19 given the significant difference of NLR between those who died and recovered from COVID-19.
背景
本研究旨在比较新型冠状病毒肺炎（COVID-19）患者与对照组的全血细胞计数（CBC）指标，并评估这些指标与COVID-19预后的关系。
方法
在这项病例对照研究中，选取了在萨里的伊玛目医院就诊的COVID-19患者（通过PCR或CT扫描确诊）。对照组从塔巴里队列人群中选取，在性别和年龄方面与病例组匹配。本研究评估了CBC、中性粒细胞与淋巴细胞比值（NLR）、血小板与淋巴细胞比值（PLR）以及疾病结局（病例组）。
结果
病例组和对照组的参与者均为527人，每组中女性有232人（44%）。对照组的血小板计数、淋巴细胞计数和血红蛋白浓度也更高（P = 0.000）。与对照组相比，COVID-19患者的NLR和PLR显著更高（P = 0.000）。NLR与疾病严重程度有显著关系。死于COVID-19的患者的NLR比康复患者高两倍（P = 0.000）。NLR和PLR诊断价值的ROC曲线分析表明，NLR和PLR的ROC曲线下面积分别为0.703（95%CI：0.64 - 0.76）和0.535（95%CI：0.46 - 0.6）。
结论
鉴于死于COVID-19和从COVID-19康复的患者之间NLR存在显著差异，NLR可作为COVID-19的预后标志物。
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