Omrani-Nava Versa, Moosazadeh Mahmood, Bahar Adeleh, Hedayatizadeh-Omran Akbar, Ahmadi Abdolrahim, Alizadeh-Navaei Reza
Gastrointestinal Cancer Research Center, Non-communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran.
Diabetes Research Center, Mazandaran University of Medical Sciences, Sari, Iran.
Caspian J Intern Med. 2023 Summer;14(3):567-571. doi: 10.22088/cjim.14.3.567.
Metabolic syndrome is a critical health concern associated with an elevated risk of chronic health problems including cardiovascular disease and diabetes. There are shreds of evidence that novel inflammatory ratios including neutrophil-to-lymphocyte, platelet-to-lymphocyte and lymphocyte-to-monocyte ratios serve as prognostic biomarkers for metabolic syndrome (MetS). This hypothesis was investigated in a cohort of the Iranian population.
selection of MetS + subjects was based on the National Cholesterol Education Program Adult Treatment Panel III criteria 3 (NCEP ATP 3). The control group consisted of participants negative for any of the five MetS criteria. Demographic and laboratory data were extracted from the Tabari cohort study.
A total of 1930 subjects including 965 Mets positive and 965 MetS criteria negative participants were evaluated. Diabetes (84.8%), hypertension (48.9%), hypertriglyceridemia (81.7%), low HDL cholesterol (70.3%), and high waist circumference (78.9%) were observed in patients. There were no differences between NLR (1.66±0.71 vs. 1.69±0.72 P=0.42), LMR (11.23±3.13 vs. 11.30±11.99, P= 0.86) and PLR (113.85±68.67 vs 114.11±35.85, P=0.91) between case and control groups, respectively. Logistic regression analysis revealed no association between ratios and MetS risk even after adjusting for potential confounders including age, gender, living place, and BMI.
In a relatively large population from Northern Iran, no association was observed between CBC-derived inflammatory ratios and the presence of MetS.
代谢综合征是一个严重的健康问题，与包括心血管疾病和糖尿病在内的慢性健康问题风险升高相关。有证据表明，包括中性粒细胞与淋巴细胞比值、血小板与淋巴细胞比值以及淋巴细胞与单核细胞比值在内的新型炎症比值可作为代谢综合征（MetS）的预后生物标志物。本研究在一组伊朗人群中对这一假设进行了调查。
根据美国国家胆固醇教育计划成人治疗小组第三次报告标准3（NCEP ATP 3）选择MetS+受试者。对照组由五项MetS标准中任何一项为阴性的参与者组成。人口统计学和实验室数据来自塔巴里队列研究。
共评估了1930名受试者，其中965名MetS阳性参与者和965名MetS标准阴性参与者。患者中观察到糖尿病（84.8%）、高血压（48.9%）、高甘油三酯血症（81.7%）、低高密度脂蛋白胆固醇（70.3%）和高腰围（78.9%）。病例组和对照组之间的中性粒细胞与淋巴细胞比值（1.66±0.71对1.69±0.72，P=0.42）、淋巴细胞与单核细胞比值（11.23±3.13对11.30±11.99，P=0.86）和血小板与淋巴细胞比值（113.85±68.67对114.11±35.85，P=0.91）分别无差异。逻辑回归分析显示，即使在调整了包括年龄、性别、居住地点和体重指数在内的潜在混杂因素后，这些比值与MetS风险之间也没有关联。
在来自伊朗北部的相对较大的人群中，未观察到基于全血细胞计数得出的炎症比值与MetS的存在之间存在关联。
