阴茎上白血病的皮肤表现——可能的影响。
Cutaneous manifestation of leukaemia on the penis-the possible implications.
作者信息
Ng Angela, Gurun Murat
机构信息
Urology Department, University Ayr Hospital, Ayr KA6 6DX, UK.
出版信息
J Surg Case Rep. 2020 Dec 31;2020(12):rjaa549. doi: 10.1093/jscr/rjaa549. eCollection 2020 Dec.
Abstract
Skin lesions are common in the patients with chronic lymphoid leukaemia (CLL); however, leukaemia cutis is a cutaneous manifestation secondary to any form of leukaemia and generally an uncommon phenomenon. They typically present on the face and neck as well as exposed areas. Our case looks at a 78-year-old gentleman with known CLL who presented with an asymptomatic raised lesion in his inner prepuce. The lesion was excised and his immunohistology staining confirms expression of CD5, CD20 and CD23 that is consistent with cutaneous manifestation of CLL. This case highlights the importance of taking leukaemia cutis into consideration in patients with known CLL with unusual features.
摘要
皮肤病变在慢性淋巴细胞白血病（CLL）患者中很常见；然而，白血病性皮肤浸润是继发于任何形式白血病的皮肤表现，通常是一种罕见现象。它们通常出现在面部、颈部以及暴露部位。我们的病例是一位78岁的已知患有CLL的男性，其阴茎内包皮出现了一个无症状的隆起病变。该病变被切除，免疫组织化学染色证实其表达CD5、CD20和CD23，这与CLL的皮肤表现一致。该病例凸显了在患有已知CLL且有异常特征的患者中考虑白血病性皮肤浸润的重要性。
相似文献
1
Cutaneous manifestation of leukaemia on the penis-the possible implications.阴茎上白血病的皮肤表现——可能的影响。
J Surg Case Rep. 2020 Dec 31;2020(12):rjaa549. doi: 10.1093/jscr/rjaa549. eCollection 2020 Dec.
2
[Chronic lymphocytic leukaemia presenting with specific cutaneous infiltrates in the absence of lymphocytosis: Two cases].[无淋巴细胞增多情况下出现特异性皮肤浸润的慢性淋巴细胞白血病：两例报告]
Ann Dermatol Venereol. 2012 Oct;139(10):641-6. doi: 10.1016/j.annder.2012.06.040. Epub 2012 Sep 1.
3
Successful treatment of leukaemia cutis with cladribine in a patient with B-cell chronic lymphocytic leukaemia.用克拉屈滨成功治疗1例B细胞慢性淋巴细胞白血病伴皮肤白血病患者。
Br J Dermatol. 2002 Oct;147(4):775-80. doi: 10.1046/j.1365-2133.2002.04880.x.
4
Leukemia cutis in B-cell chronic lymphocytic leukemia presenting as an episodic papulovesicular eruption.B细胞慢性淋巴细胞白血病中的皮肤白血病表现为发作性丘疹水疱疹。
Dermatol Online J. 2011 Sep 15;17(9):7.
5
Unusual cutaneous manifestations of B-cell chronic lymphocytic leukemia.B 细胞慢性淋巴细胞白血病的不寻常皮肤表现。
J Am Acad Dermatol. 2009 May;60(5):772-80. doi: 10.1016/j.jaad.2008.12.047.
6
Subclinical chronic lymphocytic leukaemia associated with a 13q deletion presenting initially in the skin: apropos of a case.最初表现为皮肤病变的伴有13q缺失的亚临床慢性淋巴细胞白血病：附病例报告
J Cutan Pathol. 2006 Mar;33(3):256-9. doi: 10.1111/j.0303-6987.2006.00430.x.
7
A unique case of merkel cell carcinoma and chronic lymphocytic leukaemia presenting in a single cutaneous lesion (collision tumour).一例罕见的默克尔细胞癌与慢性淋巴细胞白血病同时出现在单个皮肤损害中的病例（碰撞瘤）。
BMJ Case Rep. 2009;2009. doi: 10.1136/bcr.09.2008.1016. Epub 2009 Apr 7.
8
[Cutaneous transformation of chronic lymphoid leukemia into immunoblastic lymphoma. Cutaneous manifestation of Richter syndrome].[慢性淋巴细胞白血病皮肤转化为免疫母细胞淋巴瘤。里氏综合征的皮肤表现]
Ann Dermatol Venereol. 1995;122(8):530-3.
9
Chronic lymphocytic leukaemia skin infiltrates affecting prominent parts of the face and the scalp.
Br J Dermatol. 2006 May;154(5):981-2. doi: 10.1111/j.1365-2133.2006.07129.x.
10
CLL/SLL with initial presentation as a longstanding cutaneous plaque: a rare case.以长期存在的皮肤斑块为初始表现的慢性淋巴细胞白血病/小淋巴细胞淋巴瘤：1例罕见病例
J Cutan Pathol. 2016 Aug;43(8):717-21. doi: 10.1111/cup.12729. Epub 2016 Jun 2.
引用本文的文献
1
An unusual, delayed, solitary manifestation of a penile lesion in chronic lymphocytic leukemia.慢性淋巴细胞白血病中阴茎病变的一种不寻常、延迟出现的孤立表现。
Indian J Urol. 2023 Apr-Jun;39(2):160-162. doi: 10.4103/iju.iju_424_22. Epub 2023 Mar 31.
2
An Unusual FDG-PET/CT Documentation in Aleukemic Leukemia Cutis: Atypical Penile, Scrotal, and Leg Muscles Involvement.无白血病性白血病性皮肤的异常氟代脱氧葡萄糖正电子发射断层扫描/计算机断层扫描表现：阴茎、阴囊和腿部肌肉的非典型受累。
World J Nucl Med. 2022 Aug 16;21(3):255-260. doi: 10.1055/s-0042-1751039. eCollection 2022 Sep.
本文引用的文献
1
Chronic lymphocytic leukaemia: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up.慢性淋巴细胞白血病：ESMO诊断、治疗及随访临床实践指南
Ann Oncol. 2021 Jan;32(1):23-33. doi: 10.1016/j.annonc.2020.09.019. Epub 2020 Oct 19.
2
An urologic face of chronic lymphocytic leukemia: sequential prostatic and penis localization.慢性淋巴细胞白血病的泌尿系统表现：前列腺和阴茎相继受累。
Mediterr J Hematol Infect Dis. 2013;5(1):e2013008. doi: 10.4084/MJHID.2013.008. Epub 2013 Jan 2.
3
Unusual cutaneous manifestations of B-cell chronic lymphocytic leukemia.B 细胞慢性淋巴细胞白血病的不寻常皮肤表现。
J Am Acad Dermatol. 2009 May;60(5):772-80. doi: 10.1016/j.jaad.2008.12.047.
4
Primary cutaneous Richter syndrome: prognostic implications and review of the literature.原发性皮肤里氏综合征：预后意义及文献综述
J Am Acad Dermatol. 2009 Jan;60(1):157-61. doi: 10.1016/j.jaad.2008.07.017.
5
Leukemia cutis.皮肤白血病
Am J Clin Pathol. 2008 Jan;129(1):130-42. doi: 10.1309/WYACYWF6NGM3WBRT.
6
Specific cutaneous infiltrates of B-cell chronic lymphocytic leukemia (B-CLL) at sites typical for Borrelia burgdorferi infection.B细胞慢性淋巴细胞白血病（B-CLL）在伯氏疏螺旋体感染典型部位的特异性皮肤浸润。
J Cutan Pathol. 2002 Mar;29(3):142-7. doi: 10.1034/j.1600-0560.2002.290303.x.
7
Ulcerative balanoposthitis of the foreskin as a manifestation of chronic lymphocytic leukemia: case report and review of the literature.包皮溃疡性阴茎头炎作为慢性淋巴细胞白血病的一种表现：病例报告及文献复习
Urology. 2000 Oct 1;56(4):669. doi: 10.1016/s0090-4295(00)00735-4.
8
Specific cutaneous infiltrates of B-cell chronic lymphocytic leukemia: a clinicopathologic and prognostic study of 42 patients.B 细胞慢性淋巴细胞白血病的特异性皮肤浸润：42 例患者的临床病理及预后研究
Am J Surg Pathol. 1996 Aug;20(8):1000-10. doi: 10.1097/00000478-199608000-00009.
9
Lymphoma of the penis.阴茎淋巴瘤
J Urol. 1981 Aug;126(2):270-1. doi: 10.1016/s0022-5347(17)54472-9.
Zotero 插件