Department of Neurology, Istanbul Medipol University, Istanbul, Turkey.
Department of Restorative and Regenerative Medicine, Istanbul Medipol University, Istanbul, Turkey.
Psychiatry Clin Neurosci. 2018 Mar;72(3):152-159. doi: 10.1111/pcn.12637. Epub 2018 Feb 10.
Rifampicin exerts significant brain protective functions in multiple experimental models. Here we summarize the underlying mechanisms of the neuroprotective and pro-cognitive effects of rifampicin that are mediated by its anti-inflammatory, anti-tau, anti-amyloid, and cholinergic effects. Beyond suggesting that rifampicin shows strong brain protective effects in preclinical models of Alzheimer's disease, we also provide substantial clinical evidence for the neuroprotective and pro-cognitive effects of rifampicin. Future neuroimaging studies combined with clinical assessment scores are the following steps to be taken in this field of research.
利福平在多种实验模型中发挥显著的脑保护功能。在这里，我们总结了利福平通过其抗炎、抗tau、抗淀粉样蛋白和胆碱能作用介导的神经保护和认知促进作用的潜在机制。除了表明利福平在阿尔茨海默病的临床前模型中显示出强烈的脑保护作用外，我们还为利福平的神经保护和认知促进作用提供了大量的临床证据。未来的神经影像学研究结合临床评估评分将是这一研究领域的下一步。
