补体在心肌梗死再灌注损伤中的作用：一个未得到充分重视的治疗靶点。
The Role of Complement in Myocardial Infarction Reperfusion Injury: An Underappreciated Therapeutic Target.
作者信息
Vogel Carl-Wilhelm
机构信息
University of Hawaii Cancer Center and Department of Pathology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI, United States.
出版信息
Front Cell Dev Biol. 2020 Dec 23;8:606407. doi: 10.3389/fcell.2020.606407. eCollection 2020.
This article reviews the pathogenetic role of the complement system in myocardial infarction reperfusion injury. The complement activation pathways involved in myocardial tissue injury are identified, as are the complement-derived effector molecules. The results of past anti-complement therapies are reviewed; as the more recent therapeutic concept of complement depletion with humanized CVF described.
本文综述了补体系统在心肌梗死再灌注损伤中的致病作用。确定了参与心肌组织损伤的补体激活途径以及补体衍生的效应分子。回顾了过去抗补体治疗的结果，并描述了用人类化眼镜蛇毒因子进行补体耗竭这一最新的治疗理念。
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