Department of Senior Healthcare, Graduate School, Eulji University, Uijeongbu 11759, Republic of Korea.
Department of Internal Medicine, School of Medicine, Eulji University, Daejeon 34824, Republic of Korea.
Int J Mol Sci. 2023 Apr 30;24(9):8097. doi: 10.3390/ijms24098097.
Classifying myocardial infarction by subtype is crucial for appropriate patient management. Although troponin is currently the most commonly used biomarker, it is not a specific marker for myocardial infarction and cannot distinguish subtypes. Furthermore, previous studies have confirmed that proteins known as myocardial infarction markers could function to distinguish the type of myocardial infarction. Therefore, we identify a marker that can distinguish type 1 myocardial infarction from other diseases with elevated troponin. We used mass spectrometry to compare type 1 myocardial infarction with other conditions characterized by troponin elevation and identified new candidate markers for disease classification. We then verified these markers, along with those already known to be associated with cardiovascular disease and plaque rupture. We identified -1 acid glycoprotein 2, corticosteroid-binding globulin, and serotransferrin as potential distinguishing markers. The presence of these markers and other parameters, such as chest pain, electrocardiogram, and troponin levels from the complementary diagnostic processes, could provide valuable information to specifically diagnose type 1 myocardial infarction.
通过亚型对心肌梗死进行分类对于患者的适当管理至关重要。尽管肌钙蛋白目前是最常用的生物标志物，但它并不是心肌梗死的特异性标志物，无法区分亚型。此外，先前的研究已经证实，已知的心肌梗死标志物蛋白可以用于区分心肌梗死的类型。因此，我们确定了一种可以区分 1 型心肌梗死与其他肌钙蛋白升高疾病的标志物。我们使用质谱法比较了 1 型心肌梗死与其他以肌钙蛋白升高为特征的疾病，并确定了用于疾病分类的新候选标志物。然后，我们对这些标志物进行了验证，同时还验证了已经与心血管疾病和斑块破裂相关的标志物。我们确定 -1 酸性糖蛋白 2、皮质醇结合球蛋白和转铁蛋白为潜在的鉴别标志物。这些标志物的存在以及胸痛、心电图和补充诊断过程中的肌钙蛋白水平等其他参数，可能为明确诊断 1 型心肌梗死提供有价值的信息。
