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急性脑膜炎球菌血症的预后评分

Prognostic score in acute meningococcemia.

作者信息

Emparanza J I, Aldamiz-Echevarria L, Perez-Yarza E G, Larrañaga P, Jiminez J L, Labiano M, Ozcoidi I

机构信息

Pediatric Intensive Care Unit, Ntra. Sra. de Aranzazu Children's Hospital, San Sebastian, Spain.

出版信息

Crit Care Med. 1988 Feb;16(2):168-9. doi: 10.1097/00003246-198802000-00015.

DOI:10.1097/00003246-198802000-00015
PMID:3342629
Abstract

A prognostic score for children with acute meningococcemia is proposed. We reviewed 176 consecutive patients with acute meningococcemia with ten fatalities admitted to our pediatric ICU in the last 3 yr. The score was obtained from patients in shock, using a stepwise linear discriminant analysis of 18 clinical and laboratory variables on admission. Nine variables showed a significant discriminant power in predicting survival and death: coma, base excess, platelets, glucose, temperature, WBC, sex, purpura, and CSF. The score predicted survival in 100% and death in 91%. The predictive values were significantly better than evaluation by the frequencies of the usual clinical and laboratory variables.

摘要

提出了一种针对急性脑膜炎球菌血症患儿的预后评分。我们回顾了过去3年在我们儿科重症监护病房收治的176例连续性急性脑膜炎球菌血症患者,其中10例死亡。该评分来自休克患者,通过对入院时18项临床和实验室变量进行逐步线性判别分析得出。九个变量在预测生存和死亡方面显示出显著的判别能力:昏迷、碱剩余、血小板、葡萄糖、体温、白细胞、性别、紫癜和脑脊液。该评分预测生存的准确率为100%,预测死亡的准确率为91%。其预测价值显著优于通过常见临床和实验室变量的频率进行的评估。

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Prognostic score in acute meningococcemia.急性脑膜炎球菌血症的预后评分
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Prognostic factors of severe infectious purpura in children.儿童重症感染性紫癜的预后因素
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Clin Pediatr (Phila). 1978 Sep;17(9):680-2, 687. doi: 10.1177/000992287801700902.
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引用本文的文献

1
Prognostic utility of the semi-quantitative procalcitonin test, neutrophil count and C-reactive protein in meningococcal infection in children.降钙素原半定量检测、中性粒细胞计数及C反应蛋白在儿童脑膜炎球菌感染中的预后评估作用
Eur J Pediatr. 2006 Jan;165(1):26-9. doi: 10.1007/s00431-005-1761-5. Epub 2005 Oct 26.
2
Update on meningococcal disease with emphasis on pathogenesis and clinical management.脑膜炎球菌病最新进展,重点关注发病机制与临床管理。
Clin Microbiol Rev. 2000 Jan;13(1):144-66, table of contents. doi: 10.1128/CMR.13.1.144.
3
A normal platelet count at admission in acute meningococcal disease does not exclude a fulminant course.
急性脑膜炎球菌病入院时血小板计数正常并不能排除暴发性病程。
Intensive Care Med. 1998 Feb;24(2):157-61. doi: 10.1007/s001340050538.
4
Rapid diagnosis of acute meningococcal infections by needle aspiration or biopsy of skin lesions.通过对皮肤病变进行针吸或活检快速诊断急性脑膜炎球菌感染。
BMJ. 1993 May 8;306(6887):1229-32. doi: 10.1136/bmj.306.6887.1229.