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生物材料、纳米技术和干细胞在新冠病毒检测与治疗中的应用概述:构建应对未来全球大流行的框架

An overview of the use of biomaterials, nanotechnology, and stem cells for detection and treatment of COVID-19: towards a framework to address future global pandemics.

作者信息

Ghaffari Maryam, Mollazadeh-Bajestani Maryam, Moztarzadeh Fathollah, Uludağ Hasan, Hardy John G, Mozafari Masoud

机构信息

Biomaterials Group, Faculty of Biomedical Engineering (Center of Excellence), Amirkabir University of Technology, Tehran, Iran.

School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

出版信息

Emergent Mater. 2021;4(1):19-34. doi: 10.1007/s42247-020-00143-9. Epub 2021 Jan 5.

Abstract

A novel SARS-like coronavirus (severe acute respiratory syndrome-related coronavirus-2, SARS-CoV-2) outbreak has recently become a worldwide pandemic. Researchers from various disciplinary backgrounds (social to natural science, health and medicine, etc.) have studied different aspects of the pandemic. The current situation has revealed how the ongoing development of nanotechnology and nanomedicine can accelerate the fight against the novel viruses. A comprehensive solution to this and future pandemic outbreaks includes preventing the spread of the virus through anti-viral personal protective equipment (PPE) and anti-viral surfaces, plus efforts to encourage behavior to minimize risks. Studies of previously introduced anti-viral biomaterials and their optimization to fight against SARS-CoV-2 is the foundation of most of the recent progress. The identification of non-symptomatic patients and symptomatic patients is vital. Reviewing published research highlights the pivotal roles of nanotechnology and biomaterials in the development and efficiency of detection techniques, e.g., by applying nanotechnology and nanomedicine as part of the road map in the treatment of coronavirus disease 2019 (COVID-19) patients. In this review, we discuss efforts to deploy nanotechnology, biomaterials, and stem cells in each step of the fight against SARS-CoV-2, which may provide a framework for future efforts in combating global pandemics.

摘要

一种新型的类严重急性呼吸综合征冠状病毒(严重急性呼吸综合征相关冠状病毒2,SARS-CoV-2)引发的疫情最近已成为全球大流行。来自不同学科背景(从社会科学到自然科学、健康与医学等)的研究人员对该大流行的不同方面进行了研究。当前形势揭示了纳米技术和纳米医学的不断发展如何能够加速抗击这种新型病毒的斗争。针对此次及未来大流行疫情的全面解决方案包括通过抗病毒个人防护装备(PPE)和抗病毒表面来防止病毒传播,以及努力鼓励人们采取行为以尽量降低风险。对先前引入的抗病毒生物材料及其针对抗击SARS-CoV-2的优化研究是近期大多数进展的基础。识别无症状患者和有症状患者至关重要。回顾已发表的研究突出了纳米技术和生物材料在检测技术的发展及效能方面的关键作用,例如,将纳米技术和纳米医学作为治疗2019冠状病毒病(COVID-19)患者路线图的一部分加以应用。在本综述中,我们讨论了在抗击SARS-CoV-2的每一个环节中部署纳米技术、生物材料和干细胞的努力,这可能为未来全球抗击大流行疫情的工作提供一个框架。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bf4/7783485/0930eeae9bb3/42247_2020_143_Fig1_HTML.jpg

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