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用于检测新型冠状病毒 2019-nCoV 和其他大流行/流行性呼吸道病毒的纳米生物传感器：综述。

Nanobiosensors for the Detection of Novel Coronavirus 2019-nCoV and Other Pandemic/Epidemic Respiratory Viruses: A Review.

机构信息

Nanotechnology and Advanced Materials Program, Kuwait Institute for Scientific Research, P.O. Box 24885, Safat 13109, Kuwait.

Faculty of Materials Engineering and Mechanics, Valahia University of Targoviste, 13 Aleea Sinaia Street, 130004 Targoviste, Romania.

出版信息

Sensors (Basel). 2020 Nov 18;20(22):6591. doi: 10.3390/s20226591.

DOI:10.3390/s20226591
PMID:33218097
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7698809/
Abstract

The coronavirus disease 2019 (COVID-19) pandemic is considered a public health emergency of international concern. The 2019 novel coronavirus (2019-nCoV) or severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that caused this pandemic has spread rapidly to over 200 countries, and has drastically affected public health and the economies of states at unprecedented levels. In this context, efforts around the world are focusing on solving this problem in several directions of research, by: (i) exploring the origin and evolution of the phylogeny of the SARS-CoV-2 viral genome; (ii) developing nanobiosensors that could be highly effective in detecting the new coronavirus; (iii) finding effective treatments for COVID-19; and (iv) working on vaccine development. In this paper, an overview of the progress made in the development of nanobiosensors for the detection of human coronaviruses (SARS-CoV, SARS-CoV-2, and Middle East respiratory syndrome coronavirus (MERS-CoV) is presented, along with specific techniques for modifying the surface of nanobiosensors. The newest detection methods of the influenza virus responsible for acute respiratory syndrome were compared with conventional methods, highlighting the newest trends in diagnostics, applications, and challenges of SARS-CoV-2 (COVID-19 causative virus) nanobiosensors.

摘要

新型冠状病毒肺炎（COVID-19）疫情被认为是国际关注的突发公共卫生事件。导致此次大流行的 2019 年新型冠状病毒（2019-nCoV）或严重急性呼吸系统综合征冠状病毒 2（SARS-CoV-2）已迅速传播到 200 多个国家，并以空前的规模严重影响了各国的公共卫生和经济。在这种情况下，全世界的努力都集中在通过以下几个方向的研究来解决这个问题：（i）探索 SARS-CoV-2 病毒基因组的系统发育起源和进化；（ii）开发能够高度有效地检测新型冠状病毒的纳米生物传感器；（iii）寻找有效的 COVID-19 治疗方法；以及（iv）致力于疫苗开发。本文概述了用于检测人类冠状病毒（SARS-CoV、SARS-CoV-2 和中东呼吸综合征冠状病毒（MERS-CoV）的纳米生物传感器的研究进展，以及用于修饰纳米生物传感器表面的特定技术。比较了导致急性呼吸道综合征的流感病毒的最新检测方法与传统方法，突出了 SARS-CoV-2（COVID-19 致病病毒）纳米生物传感器在诊断、应用和挑战方面的最新趋势。

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