Department of Ophthalmology and South Australian Institute of Ophthalmology, Royal Adelaide Hospital, Adelaide, South Australia, Australia.
Department of Rheumatology, Modbury Public Hospital, Modbury, South Australia, Australia.
Clin Exp Ophthalmol. 2021 Mar;49(2):169-185. doi: 10.1111/ceo.13897. Epub 2021 Jan 10.
Giant cell arteritis is a medical emergency because of the high risk of irreversible blindness and cerebrovascular accidents. While elevated inflammatory markers, temporal artery biopsy and modern imaging modalities are useful diagnostic aids, thorough history taking and clinical acumen still remain key elements in establishing a timely diagnosis. Glucocorticoids are the cornerstone of treatment but are associated with high relapse rates and side effects. Targeted biologic agents may open up new treatment approaches in the future.
巨细胞动脉炎是一种医学急症，因为它有导致不可逆性失明和脑血管意外的高风险。虽然升高的炎症标志物、颞动脉活检和现代影像学手段有助于诊断，但详细的病史采集和临床洞察力仍然是及时诊断的关键要素。糖皮质激素是治疗的基石，但与高复发率和副作用有关。靶向生物制剂可能为未来开辟新的治疗方法。
