Department of Otolaryngology, University of Foggia, Foggia, Italy.
Unit of Otolaryngology, Department of General Surgery and Medical-Surgical Specialties, University of Catania, Catania, Italy.
J Biol Regul Homeost Agents. 2020 Nov-Dec;34(6 Suppl. 1):19-26.
Otitis media (OM) affects the middle ear and is typically characterized by earache. OM may be classified as acute (AOM) or chronic (COM), based on symptom duration. OM may be clinically suspected, but the diagnosis is usually confirmed by the otoscopy. Antibiotic therapy is frequently used in clinical practice. However, antibiotics often induce intestinal and respiratory dysbiosis associated with some clinical problems. A one-month course of a probiotic mixture (Abincol® containing Lactobacillus plantarum LP01 (1 billion of living cells), Lactobacillus lactis subspecies cremoris LLC02 (800 million living cells), and Lactobacillus delbrueckii LDD01 (200 million living cells), was prescribed in the Group A, and was compared with no addon treatment, such as the Group B. Patients were evaluated at baseline (T0), at the end of antibiotic treatment (T1), at the end of probiotic course (T2), and at the end of 3-month follow-up (T3).
中耳炎（OM）影响中耳，通常以耳痛为特征。根据症状持续时间，OM 可分为急性（AOM）或慢性（COM）。OM 可临床怀疑，但诊断通常通过耳镜检查确认。抗生素治疗在临床实践中经常使用。然而，抗生素常诱导与一些临床问题相关的肠道和呼吸道失调。在 A 组中开了一个月疗程的益生菌混合物（Abincol®，含有植物乳杆菌 LP01（10 亿活细胞）、乳双歧杆菌亚种嗜酸乳杆菌 LLC02（8 亿活细胞）和德氏乳杆菌 LDD01（2 亿活细胞）），并与无附加治疗（如 B 组）进行了比较。患者在基线（T0）、抗生素治疗结束时（T1）、益生菌疗程结束时（T2）和 3 个月随访结束时（T3）进行评估。
