Scientific Health: Education and Human Performance, Brentwood, CA, USA.
Los Medanos College Brentwood Center, Brentwood, USA.
Nutr Health. 2021 Dec;27(4):445-459. doi: 10.1177/0260106020982362. Epub 2021 Jan 11.
Those who are overfat face an onslaught of advice for losing weight, including using dietary supplements that purport to have fat burning capabilities to achieve a reduced body mass, fat mass and improvement in cardiometabolic health in combination with exercise or diet and exercise regimens.
To examine long-term effectiveness of supplements for both weight loss and improvements in cardiometabolic health for these individuals.
A PRISMA methods of systematic review was conducted from August 2018 through January 2019 using Medline, PubChem, PubMed, EBOSCO CINHAL and SPORTDiscus, and Google Scholar yielding 23,441 returns of which 21 studies (duration greater than 8 weeks with participant populations of BMI greater than 24.9) were included for meta-analysis. Meta-analysis examined pooled effect size and 95% confidence interval for: body mass, fat mass, fat-free mass, total cholesterol, high-density lipoproteins, low-density lipoproteins, resting metabolic rate. Intra-study effect sizes were compared with previously reported results for diet or diet and exercise in a 2x2 chi-square analysis for the number of studies that induced effects greater than or less than the effect size.
There is a general trend to show effectiveness (effect size greater than 0.00) for obtaining beneficial changes from use of thermogenic dietary supplements, yet the 95% confidence interval for effect size crossed 0.00 (indicating no benefit). Chi-square comparison to exercise, or combination of diet and exercise, indicates that responses induced from weight-loss supplements were less effective than what is obtained from utilizing exercise, or diet and exercise, without additional weight-loss supplements.
There appears to be limited benefit that may be derived from the inclusion of thermogenic dietary supplements to reduce body mass and improve cardiometabolic health for individuals who are overfat.
超重人群会收到大量减肥建议，包括使用据称具有燃烧脂肪功能的膳食补充剂，结合运动或饮食和运动方案来减轻体重、减少脂肪量并改善心血管代谢健康。
检查补充剂在超重人群中减肥和改善心血管代谢健康的长期效果。
使用 Medline、PubChem、PubMed、EBOSCO CINHAL 和 SPORTDiscus 以及 Google Scholar，采用 PRISMA 系统评价方法，于 2018 年 8 月至 2019 年 1 月进行了系统评价，共检索到 23,441 篇文献，其中 21 项研究（持续时间超过 8 周，参与者的 BMI 大于 24.9）被纳入荟萃分析。荟萃分析检查了体重、脂肪量、去脂体重、总胆固醇、高密度脂蛋白、低密度脂蛋白、静息代谢率的汇总效应大小和 95%置信区间。对于每个研究的效应大小，与之前报道的饮食或饮食和运动的结果进行了 2x2 卡方分析比较，以确定有多少项研究的效果大于或小于效应大小。
使用生热膳食补充剂获得有益变化的趋势普遍存在（效应大小大于 0.00），但效应大小的 95%置信区间跨越 0.00（表明无益处）。与运动或饮食和运动的卡方比较表明，减肥补充剂引起的反应不如单独使用运动或饮食和运动而不使用额外的减肥补充剂有效。
对于超重人群，添加生热膳食补充剂可能对减轻体重和改善心血管代谢健康的益处有限。
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