Department of Oral and Maxillofacial Radiology, Faculty of Dentistry, Istanbul University, Istanbul, Turkey.
Department of Tumor Pathology, Institute of Oncology, Istanbul University, Istanbul, Turkey.
Oral Radiol. 2021 Oct;37(4):560-565. doi: 10.1007/s11282-020-00500-8. Epub 2021 Jan 11.
Lipomas are the most common benign mesenchymal tumors of soft tissue. According to previous studies, 1-4% of the cases has been observed in the oral cavity. A histological variant of lipoma featuring bone formation is called osteolipoma and has been very rarely observed (less than 1% of the total). In order to make a meaningful addition to this rare knowledge base, our study aims to provide a literature review and to report an additional case of osteolipoma.
An electronic search in the PubMed database with the keyword "osteolipoma" was conducted. Among 69 search results, only the cases of osteolipoma located in the "oral cavity" were included in this study. The findings of the previously reported 20 cases (in English) of osteolipoma of the oral cavity were organized in a table along with a new case of osteolipoma located in the mandibular buccal vestibule with radiological and histopathological findings provided by the authors.
Osteolipoma affects both sexes and usually emerges in middle-aged or elderly patients with a long history of slow progression. Different imaging techniques may be utilized in the radiographic evaluation.
Differential diagnosis includes a wide range of lesions; therefore, the clinical and radiographic evaluation should be confirmed by histopathological examination. The suggested treatment is complete surgical excision and follow-up, and the prognosis is generally good.
脂肪瘤是最常见的软组织良性间叶组织肿瘤。根据以往的研究,1-4%的病例发生在口腔内。一种具有骨形成特征的脂肪瘤组织学变体称为骨脂肪瘤,极为罕见(不到总数的 1%)。为了在这一罕见知识库中做出有意义的补充,我们的研究旨在提供文献综述,并报告一例额外的骨脂肪瘤病例。
在 PubMed 数据库中使用关键字“osteolipoma”进行电子搜索。在 69 个搜索结果中,仅纳入了本研究中位于“口腔”的骨脂肪瘤病例。作者按照表格形式整理了之前报道的 20 例(英文)口腔骨脂肪瘤病例的发现,并附上了作者提供的新的位于下颌颊侧前庭骨脂肪瘤的影像学和组织病理学发现。
骨脂肪瘤可影响两性,通常发生于中老年患者,具有缓慢进展的长期病史。不同的影像学技术可用于放射学评估。
鉴别诊断包括广泛的病变;因此,临床和影像学评估应通过组织病理学检查加以证实。建议的治疗方法是完全手术切除和随访,预后通常良好。