Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, Shanxi, China.
Institute of Biomedicine and Health, Shanxi University, Taiyuan 030006, Shanxi, PR China.
Aging (Albany NY). 2021 Jan 10;13(3):3798-3818. doi: 10.18632/aging.202340.
From the points of view of phenomena and experience, aging and constipation are inextricably correlated. However, experimental support and underlying mechanisms are still lacking. The purpose of this study is to explore the relationships between aging and constipation from the perspectives of fecal metabolites and network pharmacology. The behavioral analyses of aging and constipation were carried out on both aging rats and constipation rats. We found that aging rats exhibited not only significant aging behaviors but also significant constipation behaviors, while constipation rats exhibited both significant constipation and aging behaviors. Additionally, fecal metabolomics was carried out and found that 23 metabolites were aging-related and 22 metabolites were constipation-related. Among them, there were 16 differential metabolites in common with 11 metabolic pathways. Network pharmacology was applied to construct the target-pathway network of aging and constipation, revealing that pathway in cancer was the most associated signaling pathway. The current findings will provide not only a novel perspective for understanding aging and constipation, but a theoretical association and understanding the traditional Chinese medicine theory and the Western medicine theory about aging and constipation, as well as support for the clinical research and development of medicine related to constipation in the elderly.
从现象和经验的角度来看，衰老和便秘是密切相关的。然而，目前还缺乏实验支持和潜在机制。本研究旨在从粪便代谢物和网络药理学的角度探讨衰老和便秘之间的关系。我们对衰老和便秘大鼠进行了衰老和便秘行为的分析。结果发现，衰老大鼠不仅表现出明显的衰老行为，还表现出明显的便秘行为，而便秘大鼠则表现出明显的便秘和衰老行为。此外，我们还进行了粪便代谢组学研究，发现了 23 种与衰老相关的代谢物和 22 种与便秘相关的代谢物。其中，有 16 种差异代谢物与 11 条代谢途径有关。应用网络药理学构建衰老和便秘的靶标-通路网络，发现癌症通路是最相关的信号通路。这些发现不仅为理解衰老和便秘提供了新的视角，还为理解衰老和便秘的中医理论和西医理论提供了理论联系，并为与老年人便秘相关的医学的临床研究和开发提供了支持。
