Romslo I, Talstad I
Department Clin. Chem., University Hospital, Trondheim, Norway.
Eur J Haematol. 1988 Jan;40(1):79-82. doi: 10.1111/j.1600-0609.1988.tb00801.x.
Day-to-day variations in serum iron, serum iron binding capacity, serum ferritin and erythrocyte protoporphyrin were determined on 2 successive days in 48 patients with anaemia. The correlation coefficients between the paired determinations were 0.86, 0.89, 0.95 and 0.95, and the day-to-day coefficients of variation (in per cent) were 33, 11, 12 and 13 for serum iron, serum iron binding capacity, erythrocyte protoporphyrin and serum ferritin, respectively. Thus, in patients with anaemia, day-to-day variations in serum iron, serum iron binding capacity, erythrocyte protoporphyrin and serum ferritin are at least as high as in healthy controls. The results indicate important limitations in the use, particularly, of serum iron in the clinical investigation of anaemia.
对48例贫血患者连续两天测定血清铁、血清铁结合能力、血清铁蛋白和红细胞原卟啉的每日变化情况。配对测定之间的相关系数分别为0.86、0.89、0.95和0.95，血清铁、血清铁结合能力、红细胞原卟啉和血清铁蛋白的每日变异系数（百分比）分别为33、11、12和13。因此，在贫血患者中，血清铁、血清铁结合能力、红细胞原卟啉和血清铁蛋白的每日变化至少与健康对照者一样高。结果表明，特别是血清铁在贫血临床研究中的应用存在重要局限性。
