Laboratorio de Referencia de Cataluña, Barcelona, Spain; Spanish Network for Research in Infectious Diseases (REIPI RD16/0016/0011), Instituto de Salud Carlos III, 28029 Madrid, Spain.
Spanish Network for Research in Infectious Diseases (REIPI RD16/0016/0011), Instituto de Salud Carlos III, 28029 Madrid, Spain; Infectious Department, Ramon y Cajal University Hospital, Madrid, Spain.
Anaerobe. 2021 Jun;69:102318. doi: 10.1016/j.anaerobe.2021.102318. Epub 2021 Jan 8.
A 79-year-old male was diagnosed with a total knee prosthetic infection. He had a history of an episode of Clostridioides difficile-associated diarrhoea a year ago. Clostridioides difficile was isolated from the joint fluid and intraoperative tissue samples, and ribotyping demonstrated that the strain was the same that had caused the diarrheic episode, an infrequent ribotype (RT534). The genetic relatedness suggests that the initial infection occurred during that hospitalization, resulting in a chronic prosthetic infection. We have carried out an extensive literature review of all the cases reported in scientific databases of Clostridioides difficile infections with extraintestinal presentation and their relationship with previous colitis.
一位 79 岁男性被诊断为全膝关节假体感染。他在一年前曾有过一次艰难梭菌相关性腹泻发作。艰难梭菌从关节液和术中组织样本中分离出来，基因指纹图谱显示该菌株与引起腹泻发作的菌株相同，这是一种罕见的基因指纹图谱（RT534）。基因相关性表明最初的感染发生在那次住院期间，导致慢性假体感染。我们对所有在科学数据库中报告的艰难梭菌感染的病例进行了广泛的文献回顾，这些病例表现为肠道外表现，并与以前的结肠炎有关。
