信号通路、非编码 RNA 与 DNA 损伤反应的串扰：癌症进展中的新兴参与者。
The cross-talk between signaling pathways, noncoding RNAs and DNA damage response: Emerging players in cancer progression.
机构信息
Department of Biochemistry and Clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Science, Tabriz, Iran; Student's Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
Department of Biochemistry and Clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Science, Tabriz, Iran.
出版信息
DNA Repair (Amst). 2021 Feb;98:103036. doi: 10.1016/j.dnarep.2020.103036. Epub 2021 Jan 7.
The DNA damage response (DDR) pathway's primary purpose is to maintain the genome structure's integrity and stability. A great deal of effort has done to understand the exact molecular mechanisms of non-coding RNAs, such as lncRNA, miRNAs, and circRNAs, in distinct cellular and genomic processes and cancer progression. In this regard, the ncRNAs possible regulatory role in DDR via modulation of key components expression and controlling repair signaling pathway activation is validated. Therefore, in this article, we will discuss the latest developments of ncRNAs contribution in different aspects of DNA repair through regulation of ATM-ATR, P53, and other regulatory signaling pathways.
DNA 损伤反应（DDR）途径的主要目的是维持基因组结构的完整性和稳定性。人们已经做了大量的工作来了解非编码 RNA（如 lncRNA、miRNA 和 circRNA）在不同的细胞和基因组过程以及癌症进展中的精确分子机制。在这方面，已经验证了 ncRNA 通过调节关键成分的表达和控制修复信号通路的激活，在 DDR 中可能发挥的调节作用。因此，在本文中，我们将讨论 ncRNA 通过调节 ATM-ATR、P53 和其他调节信号通路在 DNA 修复的不同方面的最新研究进展。
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