Tianjin Medical University School & Hospital of Stomatology, Tianjin, 300070, China.
Biomedical Barriers Research Center, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin Key Laboratory of Biomedical Materials, Tianjin, 300192, China.
Colloids Surf B Biointerfaces. 2021 Mar;199:111560. doi: 10.1016/j.colsurfb.2021.111560. Epub 2021 Jan 6.
Polymeric particles with non-spherical shape or coarse surface have distinct advantages for drug delivery, tissue regeneration and immunomodulation respectively, but it is not easy to control polymeric microparticles in required geometry and surface texture simultaneously. In this study, polymeric non-spherical microparticles with coarse surface were successfully prepared by double emulsion-solvent evaporation technique in the presence of ammonium bicarbonate and the formation mechanism was proposed. In addition, simvastatin was encapsulated in poly[lactic-co-(glycolic acid)] (PLGA) non-spherical microparticles with coarse surface by the same technique and the release kinetics in vitro was fitted as well, which not only enrich the encapsulation techniques of liposoluble drugs in polymeric non-spherical carriers but also envision the potential application for alveolar ridge preservation with local delivery of simvastatin.
具有非球形形状或粗糙表面的聚合粒子分别在药物传递、组织再生和免疫调节方面具有明显的优势，但同时控制聚合微球具有所需的几何形状和表面纹理并不容易。在这项研究中，通过在存在碳酸氢铵的情况下使用双乳液-溶剂蒸发技术成功制备了具有粗糙表面的聚合非球形微球，并提出了其形成机制。此外，辛伐他汀通过相同的技术被包封在具有粗糙表面的聚（乳酸-共-（乙醇酸））（PLGA）非球形微球中，并且体外释放动力学也进行了拟合，这不仅丰富了脂溶性药物在聚合非球形载体中的包封技术，而且还设想了通过局部递辛伐他汀用于牙槽嵴保存的潜在应用。
