Sherstneva Anastasia A, Demina Tatiana S, Monteiro Ana P F, Akopova Tatiana A, Grandfils Christian, Ilangala Ange B
Enikolopov Institute of Synthetic Polymeric Materials, Russian Academy of Sciences, 70 Profsouznaya Str., 117393 Moscow, Russia.
Institute for Regenerative Medicine, Sechenov First Moscow State Medical University, 8-2 Trubetskaya Str., 119991 Moscow, Russia.
Polymers (Basel). 2022 Mar 24;14(7):1314. doi: 10.3390/polym14071314.
Tissue engineering and cell therapy are very attractive in terms of potential applications but remain quite challenging regarding the clinical aspects. Amongst the different strategies proposed to facilitate their implementation in clinical practices, biodegradable microparticles have shown promising outcomes with several advantages and potentialities. This critical review aims to establish a survey of the most relevant materials and processing techniques to prepare these micro vehicles. Special attention will be paid to their main potential applications, considering the regulatory constraints and the relative easiness to implement their production at an industrial level to better evaluate their application in clinical practices.
组织工程和细胞治疗在潜在应用方面极具吸引力，但在临床应用方面仍颇具挑战。在为促进其在临床实践中的应用而提出的不同策略中，可生物降解微粒已展现出具有多种优势和潜力的良好成果。这篇批判性综述旨在对制备这些微载体的最相关材料和加工技术进行调查。考虑到监管限制以及在工业层面实现其生产的相对简易性，将特别关注它们的主要潜在应用，以便更好地评估它们在临床实践中的应用。
