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用于提高抗生素效率的复合聚（3-羟基丁酸酯-3-羟基戊酸酯）-壳聚糖微球

Composite P(3HB-3HV)-CS Spheres for Enhanced Antibiotic Efficiency.

作者信息

Gherasim Oana, Grumezescu Alexandru Mihai, Ficai Anton, Grumezescu Valentina, Holban Alina Maria, Gălățeanu Bianca, Hudiță Ariana

机构信息

Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest, 011061 Bucharest, Romania.

Lasers Department, National Institute for Lasers, Plasma, and Radiation Physics, RO-77125 Magurele, Romania.

出版信息

Polymers (Basel). 2021 Mar 23;13(6):989. doi: 10.3390/polym13060989.

DOI:10.3390/polym13060989
PMID:33807077
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8004896/
Abstract

Natural-derived biopolymers are suitable candidates for developing specific and selective performance-enhanced antimicrobial formulations. Composite polymeric particles based on poly(3-hydroxybutyrate-co-3-hydroxyvalerate) and chitosan, P(3HB-3HV)-CS, are herein proposed as biocompatible and biodegradable delivery systems for bioproduced antibiotics: bacitracin (Bac), neomycin (Neo) and kanamycin (Kan). The stimuli-responsive spheres proved efficient platforms for boosting the antibiotic efficiency and antibacterial susceptibility, as evidenced against Gram-positive and Gram-negative strains. Absent or reduced proinflammatory effects were evidenced on macrophages in the case of Bac-/Neo- and Kan-loaded spheres, respectively. Moreover, these systems showed superior ability to sustain and promote the proliferation of dermal fibroblasts, as well as to preserve their ultrastructure (membrane and cytoskeleton integrity) and to exhibit anti-oxidant activity. The antibiotic-loaded P(3HB-3HV)-CS spheres proved efficient alternatives for antibacterial strategies.

摘要

天然衍生的生物聚合物是开发具有特定和选择性性能增强的抗菌制剂的合适候选材料。本文提出基于聚（3-羟基丁酸酯-co-3-羟基戊酸酯）和壳聚糖的复合聚合物颗粒P(3HB-3HV)-CS，作为生物生产抗生素（杆菌肽（Bac）、新霉素（Neo）和卡那霉素（Kan））的生物相容性和可生物降解的递送系统。这些刺激响应性球体被证明是提高抗生素效率和抗菌敏感性的有效平台，这在针对革兰氏阳性和革兰氏阴性菌株的实验中得到了证明。分别在载有Bac-/Neo-和Kan的球体的情况下，巨噬细胞上未观察到或观察到炎症前效应减弱。此外，这些系统显示出维持和促进真皮成纤维细胞增殖的卓越能力，以及保持其超微结构（膜和细胞骨架完整性）并表现出抗氧化活性的能力。载有抗生素的P(3HB-3HV)-CS球体被证明是抗菌策略的有效替代方案。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e0a/8004896/3d44d5ffc631/polymers-13-00989-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e0a/8004896/7aab3aa1d674/polymers-13-00989-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e0a/8004896/83ad7ff1dc8d/polymers-13-00989-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e0a/8004896/e29e8a14cc9d/polymers-13-00989-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e0a/8004896/179390cb3b36/polymers-13-00989-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e0a/8004896/fc45b5c777d0/polymers-13-00989-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e0a/8004896/ec026b298571/polymers-13-00989-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e0a/8004896/19f27c27e816/polymers-13-00989-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e0a/8004896/6cdc05abdbc7/polymers-13-00989-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e0a/8004896/3d44d5ffc631/polymers-13-00989-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e0a/8004896/7aab3aa1d674/polymers-13-00989-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e0a/8004896/83ad7ff1dc8d/polymers-13-00989-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e0a/8004896/e29e8a14cc9d/polymers-13-00989-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e0a/8004896/179390cb3b36/polymers-13-00989-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e0a/8004896/fc45b5c777d0/polymers-13-00989-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e0a/8004896/ec026b298571/polymers-13-00989-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e0a/8004896/19f27c27e816/polymers-13-00989-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e0a/8004896/6cdc05abdbc7/polymers-13-00989-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e0a/8004896/3d44d5ffc631/polymers-13-00989-g009.jpg

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