Nagai Atsushi, Miller Jason B, Kos Petra, Elkassih Sussana, Xiong Hu, Siegwart Daniel J
Simmons Comprehensive Cancer Center, Department of Biochemistry, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, United States.
Department of Materials Molecular Science, Institute for Molecular Science, National Institutes of Natural Sciences, 5-1 Higashiyama, Myodaiji, Okazaki 444-8787, Japan.
ACS Biomater Sci Eng. 2015 Dec 14;1(12):1206-1210. doi: 10.1021/acsbiomaterials.5b00389. Epub 2015 Nov 3.
We report a bioinspired upconversion (UC) system using a cellulose template, in which an aggregated platinum(II)-tetraphenylporphyrin (PtTPP) sensitizer is able to excite Rhodamine B as an emitter, enabling near-infrared (NIR)-to-orange wavelength conversions. The comodified cellulose was observed to undergo J aggregation of PtTPP in DMSO solution, as indicated by broad, weak absorption bands in the NIR region of the absorption spectrum. Excitation of these NIR J aggregation peaks of PtTPP led to efficient UC emission in the orange wavelength region. These materials were shown to exhibit UC properties in biological settings both in vitro and in vivo, demonstrating utility of UC for tumor imaging.
我们报道了一种利用纤维素模板的仿生上转换（UC）系统，其中聚集的铂（II）-四苯基卟啉（PtTPP）敏化剂能够激发罗丹明B作为发射体，实现近红外（NIR）到橙色波长的转换。观察到共修饰的纤维素在二甲基亚砜溶液中使PtTPP发生J聚集，这由吸收光谱近红外区域宽而弱的吸收带表明。对PtTPP这些近红外J聚集峰的激发导致在橙色波长区域产生高效的上转换发射。这些材料在体外和体内的生物环境中均表现出上转换特性，证明了上转换在肿瘤成像中的实用性。
