中药外治膝骨关节炎疗效与安全性的比较：系统评价和网络荟萃分析方案。
A comparison of the efficacy and safety of traditional Chinese medicine external treatment for the knee osteoarthritis: A protocol for systematic review and network meta-analysis.
机构信息
First Clinical College, Shandong University of Traditional Chinese Medicine, Jinan.
Shandong College of Traditional Chinese Medicine, Yantai.
出版信息
Medicine (Baltimore). 2021 Jan 8;100(1):e24115. doi: 10.1097/MD.0000000000024115.
BACKGROUND
Knee osteoarthritis (KOA), also known as degenerative osteoarthritis, is a common and frequently occurring disease in orthopedics with cartilage degeneration as the pathogenic cause and articular bone hyperplasia as the sign. Many studies have confirmed that KOA can be effectively treated by traditional Chinese medicine (TCM) external treatment. So we take advantage of the method of network meta-analysis to systematically compare the efficacy and safety of different types of TCM external treatment for the KOA.
METHODS
We will research on external treatment of KOA by traditional Chinese medicine using randomized controlled trials (RCTs) in search database (EMBASE, PubMed, Web of Science, Chinese National Knowledge Infrastructure [CNKI], Weipu database [VIP], Wanfang, and China BioMedical Literature [CBM]). The data and evidence obtained will be processed using Stata 15.0 and WinBUGS 1.4.3.
RESULTS
We will evaluate the efficacy and safety of traditional Chinese medicine external treatment for the knee osteoarthritis in this study.
CONCLUSION
This study will provide a new regimen for KOA treatment. It has extremely high reference value.
INPLASY REGISTRATION NUMBER
INPLASY2020120001.
DOI NUMBER
: 10.37766/inplasy2020.12.0001.
背景
膝骨关节炎（KOA），又称退行性骨关节炎，是骨科的常见病和多发病，以软骨退变为致病原因，以关节骨增生为表现。许多研究证实，中医药外治法可有效治疗 KOA。因此，我们利用网络荟萃分析的方法，系统比较了不同类型中医药外治法治疗 KOA 的疗效和安全性。
方法
我们将通过在检索数据库（EMBASE、PubMed、Web of Science、中国知网[CNKI]、维普数据库[VIP]、万方和中国生物医学文献[CBM]）中搜索随机对照试验（RCTs），对 KOA 的中医药外治法进行研究。使用 Stata 15.0 和 WinBUGS 1.4.3 处理获得的数据和证据。
结果
我们将在本研究中评估中医药外治法治疗膝骨关节炎的疗效和安全性。
结论
本研究将为 KOA 的治疗提供新的方案，具有极高的参考价值。
INPLASY 注册号：INPLASY2020120001。
DOI 号：10.37766/inplasy2020.12.0001。
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