From Reproductive Medical Center, Department of Obstetrics and Gynecology, The Second Hospital of Jilin University.
From Cancer Center.
Medicine (Baltimore). 2021 Jan 8;100(1):e24134. doi: 10.1097/MD.0000000000024134.
Ovarian cancer (OC), a common malignant heterogeneous gynecological tumor, is the primary cause of cancer-related death in women worldwide. Adenylate kinase (AK) 7 belongs to the adenylate kinase (AK) family and is a cytosolic isoform of AK. Recent studies have demonstrated that AK7 is expressed in several human diseases, including cancer. However, there is a scarcity of reports on the relationship between AK7 and OC. Here, we compared the expression of AK7 in normal and cancerous ovarian tissues from The Cancer Genome Atlas database and used the c2 test to assess the correlation between AK7 levels and the clinical symptoms of OC. Finally, the prognostic significance of AK7 in OC was determined using the Kaplan-Meier analyses and Cox regression and performed gene set enrichment analysis to detect any relevant signaling pathways. We found that AK7 levels were substantially downregulated in OC than that in normal ovarian tissues (P < .001). Low AK7 levels were related to the patients' age (P = .0093) in OC. The median overall survival (OS) of patients with low AK7-expressing OC was shorter than patients with high AK7-expressing OC (P = .019). The Cox regression analysis (multivariate) identified low AK7 levels were independently related to the prognosis of OC (HR 1.34; P = .048). Our study demonstrated that the downregulated levels of AK7 could serve as an independent prognostic indicator for the OS in OC. Additionally, gene set enrichment analysis revealed that EMT, apical junction, TGF-b signaling, UV response, and myogenesis were associated in the low AK7 expression phenotype (NOM P < .05).
卵巢癌（OC）是一种常见的恶性异质性妇科肿瘤，是全球女性癌症相关死亡的主要原因。腺苷酸激酶（AK）7 属于腺苷酸激酶（AK）家族，是 AK 的细胞质同工酶。最近的研究表明，AK7 在包括癌症在内的几种人类疾病中表达。然而，关于 AK7 与 OC 的关系的报道很少。在这里，我们比较了来自癌症基因组图谱数据库的正常和癌性卵巢组织中 AK7 的表达，并使用 c2 检验评估 AK7 水平与 OC 临床症状之间的相关性。最后，使用 Kaplan-Meier 分析和 Cox 回归确定 AK7 在 OC 中的预后意义，并进行基因集富集分析以检测任何相关的信号通路。我们发现，AK7 在 OC 中的表达水平明显低于正常卵巢组织（P<0.001）。在 OC 中，低 AK7 水平与患者的年龄有关（P=0.0093）。低 AK7 表达 OC 患者的中位总生存期（OS）短于高 AK7 表达 OC 患者（P=0.019）。Cox 回归分析（多变量）确定低 AK7 水平与 OC 的预后独立相关（HR 1.34；P=0.048）。我们的研究表明，AK7 水平的下调可作为 OC OS 的独立预后指标。此外，基因集富集分析表明，EMT、顶端连接、TGF-b 信号、UV 反应和肌生成与低 AK7 表达表型相关（NOM P<0.05）。
