Hou Lin, Zhang Xueying, Jiao Yan, Li Yanqing, Zhao Yuechen, Guan Yinuo, Liu Ziling
Cancer Center, The First Hospital of Jilin University.
Reproductive Medical Center, Department of Obstetrics and Gynecology, The Second Hospital of Jilin University.
Medicine (Baltimore). 2019 May;98(19):e15698. doi: 10.1097/MD.0000000000015698.
Ovarian cancer (OC) is one of the most common gynecological malignancies and owns the highest mortality rate among all gynecological malignant tumors. ATP binding cassette subfamily B member 9 (ABCB9) is an antigen processing-like (TAPL) transporter that has been found to be involved in the development and progression of various malignant tumors in accumulating reports. However, the potential role of ABCB9 in OC has never been reported.In this study, ABCB9 expression was evaluated in normal ovarian tissues and ovarian cancer tissues using The Cancer Genome Atlas (TCGA) database. And the associations between ABCB9 expression and clinical parameters of patients of OC were evaluated by Chi-square tests. Kaplan-Meier analysis and Cox regression analysis were performed to evaluate the prognostic significance of ABCB9. GSEA was performed to explore related signaling pathway.ABCB9 expression levels were significantly decreased in OC compared with normal ovarian tissues (P < .001). Low ABCB9 expression was associated with survival status (P = .0148) in OC. Kaplan-Meier analysis showed that low ABCB9 expression was associated with poor overall survival in OC (P = .0032). Multivariable Cox regression analysis indicated that low ABCB9 expression was an independent prognostic factor (HR 0.64; P = .01) in OC patients. Besides, epithelial mesenchymal transition, UV response, and TGF-β signaling were enriched in low ABCB9 expression phenotype, respectively, examined by gene set enrichment analysis.These results suggest that ABCB9 is an independent prognostic indicator in OC with certain clinical significance.
卵巢癌（OC）是最常见的妇科恶性肿瘤之一，在所有妇科恶性肿瘤中死亡率最高。ATP结合盒亚家族B成员9（ABCB9）是一种抗原加工样（TAPL）转运蛋白，越来越多的报道发现它参与了各种恶性肿瘤的发生和发展。然而，ABCB9在OC中的潜在作用尚未见报道。在本研究中，使用癌症基因组图谱（TCGA）数据库评估了正常卵巢组织和卵巢癌组织中ABCB9的表达。通过卡方检验评估ABCB9表达与OC患者临床参数之间的关联。进行Kaplan-Meier分析和Cox回归分析以评估ABCB9的预后意义。进行基因集富集分析（GSEA）以探索相关信号通路。与正常卵巢组织相比，OC中ABCB9表达水平显著降低（P<0.001）。低ABCB9表达与OC患者的生存状态相关（P=0.0148）。Kaplan-Meier分析表明，低ABCB9表达与OC患者较差的总生存期相关（P=0.0032）。多变量Cox回归分析表明，低ABCB9表达是OC患者的独立预后因素（HR 0.64；P=0.01）。此外，通过基因集富集分析检测发现，上皮-间质转化、紫外线反应和TGF-β信号通路在低ABCB9表达表型中分别富集。这些结果表明，ABCB9是OC的独立预后指标，具有一定的临床意义。
