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XXYLT1 甲基化有助于肺腺癌的发生：甲基化与肺腺癌。

XXYLT1 methylation contributes to the occurrence of lung adenocarcinoma: Methylation and lung adenocarcinoma.

机构信息

Institute of Cancer Research and Basic Medical Sciences of Chinese Academy of Sciences.

Cancer Hospital of University of Chinese Academy of Sciences.

出版信息

Medicine (Baltimore). 2021 Jan 8;100(1):e24150. doi: 10.1097/MD.0000000000024150.

DOI:10.1097/MD.0000000000024150
PMID:33429795
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7793369/
Abstract

BACKGROUND

There is evidence that DNA methylation play major roles in lung cancer. In our previously study, C3 or f21 , also referred to as XXYLT1, rs2131877 polymorphism is associated with a reduced risk of lung adenocarcinoma. So, we explored the role of XXYLT1 methylation in lung adenocarcinoma.

METHODS

This study was conducted in 2 steps. In the first step, we recruited 15 patients with lung adenocarcinoma. Cancer tissues and para-carcinoma tissues were obtained from each of the patients. In the second step, 150 patients with lung adenocarcinom were enrolled, and cancer and normal lung tissue were obtained from each patients, respectively. The expression levels of XXYLT1 mRNA were determined, the deoxyribonucleic acid methylation status was analyzed by MassARRAY Spectrometry. The methylation data of individual units were generated by EpiTyper v1.0.5 software.

RESULTS

The XXYLT1 mRNA expression was significantly lower in cancer tissues than in para-carcinoma and normal lung tissues. Meanwhile, the methylation rates of three CpG units (CpG_23, CpG_25, and CpG_60.61.62.63.64.65) within the XXYLT1 gene were higher in cancer tissues compared to the para-carcinoma and the normal lung tissues. This difference was particularly significant in male patients.

CONCLUSIONS

Our results suggested that methylation of XXYLT1 may have significance in the pathogenesis of lung adenocarcinoma.

摘要

背景

有证据表明，DNA 甲基化在肺癌中发挥重要作用。在我们之前的研究中，C3 或 f21，也称为 XXYLT1，rs2131877 多态性与肺腺癌风险降低相关。因此，我们探讨了 XXYLT1 甲基化在肺腺癌中的作用。

方法

本研究分两步进行。第一步，我们招募了 15 例肺腺癌患者。每位患者的癌组织和癌旁组织均取自每位患者。第二步，共纳入 150 例肺腺癌患者，分别从每位患者中获取癌组织和正常肺组织。通过 MassARRAY 质谱法测定 XXYLT1 mRNA 的表达水平，分析脱氧核糖核酸的甲基化状态。通过 EpiTyper v1.0.5 软件生成个体单位的甲基化数据。

结果

XXYLT1 mRNA 在癌组织中的表达明显低于癌旁组织和正常肺组织。同时，XXYLT1 基因内三个 CpG 单元（CpG_23、CpG_25 和 CpG_60.61.62.63.64.65）的甲基化率在癌组织中高于癌旁组织和正常肺组织。这种差异在男性患者中尤为显著。

结论

我们的结果表明，XXYLT1 的甲基化可能在肺腺癌的发病机制中具有重要意义。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cf6/7793369/897b81d9740d/medi-100-e24150-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cf6/7793369/842b24120604/medi-100-e24150-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cf6/7793369/dc614f8dc827/medi-100-e24150-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cf6/7793369/a374faebd73c/medi-100-e24150-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cf6/7793369/dfe690528c90/medi-100-e24150-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cf6/7793369/897b81d9740d/medi-100-e24150-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cf6/7793369/842b24120604/medi-100-e24150-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cf6/7793369/dc614f8dc827/medi-100-e24150-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cf6/7793369/a374faebd73c/medi-100-e24150-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cf6/7793369/dfe690528c90/medi-100-e24150-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cf6/7793369/897b81d9740d/medi-100-e24150-g005.jpg

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