关于血浆胆固醇降低引起吸收不良导致胆结石形成风险的前瞻性研究。
Prospective study of malabsorption induced risk of gall stone formation in relation to fall in plasma cholesterol.
作者信息
Sørensen T I, Andersen B, Hylander E, Jensen L I, Laursen K, Klein H C
机构信息
Department of Medicine, Hvidovre University Hospital, Copenhagen, Denmark.
出版信息
Gut. 1988 Jan;29(1):108-13. doi: 10.1136/gut.29.1.108.
The relationship between cholesterol in plasma and risk of gall stone formation was investigated in 210 obese patients who underwent jejunoileal bypass surgery and were free of gall stone disease at the time. Among 185, successfully reexamined on average 19 months after surgery, 26 (14%) developed gall stones. The fall in plasma cholesterol after surgery exhibited a U-shaped relation to risk of gall stone formation with a minimum risk around the average fall (2.6 mmol/l). This was confirmed by multivariate logistic regression analysis (p less than 0.01) taking into account other possible determinants. The relation was not significantly dependent on weight loss or ratio between jejunum and ileum left in function. The study suggests that malabsorption induced fall in plasma cholesterol is related to risk of gall stone formation by two oppositely working mechanisms, one enhancing and one reducing the risk.
对210例接受空肠回肠分流术且当时无胆结石疾病的肥胖患者，研究了血浆胆固醇与胆结石形成风险之间的关系。在185例术后平均19个月成功接受复查的患者中，26例（14%）出现了胆结石。术后血浆胆固醇的下降与胆结石形成风险呈U形关系，平均下降幅度（2.6 mmol/l）左右时风险最低。多因素逻辑回归分析（p<0.01）在考虑其他可能的决定因素后证实了这一点。这种关系并不显著依赖于体重减轻或保留功能的空肠与回肠的比例。该研究表明，吸收不良导致的血浆胆固醇下降与胆结石形成风险通过两种相反作用的机制相关，一种增加风险，一种降低风险。
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