Ahlberg J, Angelin B, Einarsson K, Hellström K, Leijd B
Gastroenterology. 1980 Jul;79(1):90-4.
The lipid composition of fasting gallbladder bile obtained under standardized conditions was determined in healthy controls and in patients with hyperlipoproteinemia without gallstones. Altogether 23 normolipidemic controls (10 males and 13 females) and 50 hyperlipidemic patients (31 type IIa, 7 type IIb, and 12 type IV) were studied; all were less than 15% overweight. The cholesterol saturation averaged 96 +/- 5% (mean +/- SEM) in the controls, and 10 of them had bile supersaturated with cholesterol. There was no difference between males and females. An increased saturation with age was seen in females. A normal biliary cholesterol saturation (102 +/- 3%) was found in patients with hyperlipoproteinemia type IIa; this was true also for the subgroup with established familial hypercholesterolemia. All patients with hyperlipoproteinemia type IIb and 10 of those with type IV had saturated bile (135 +/- 8% and 121 +/- 6%, respectively). The results suggest an association between certain forms of hyperlipoproteinemia and the development of supersaturated bile. Since fasting gallbladder bile supersaturated with cholesterol is considered to precede gallstone formation, the present results may explain previous findings of an increased prevalence of gallstone disease in patients with hypertriglyceridemia.
在健康对照组和无胆结石的高脂蛋白血症患者中，测定了在标准化条件下获取的空腹胆囊胆汁的脂质成分。共研究了23名血脂正常的对照者（10名男性和13名女性）和50名高脂血症患者（31例IIa型、7例IIb型和12例IV型）；所有患者超重均低于15%。对照组的胆固醇饱和度平均为96±5%（平均值±标准误），其中10人的胆汁胆固醇超饱和。男性和女性之间无差异。女性中随年龄增长饱和度增加。IIa型高脂蛋白血症患者的胆汁胆固醇饱和度正常（102±3%）；患有家族性高胆固醇血症的亚组也是如此。所有IIb型高脂蛋白血症患者和IV型患者中的10人胆汁饱和（分别为135±8%和121±6%）。结果表明某些形式的高脂蛋白血症与过饱和胆汁的形成之间存在关联。由于胆固醇过饱和的空腹胆囊胆汁被认为先于胆结石形成，目前的结果可能解释了先前关于高甘油三酯血症患者胆结石疾病患病率增加的发现。
