Thornton J R, Heaton K W, Macfarlane D G
Br Med J (Clin Res Ed). 1981 Nov 21;283(6303):1352-4. doi: 10.1136/bmj.283.6303.1352.
The association of cholesterol gall stones with coronary artery disease is controversial. To investigate this possible relation at the biochemical level, bile cholesterol saturation and the plasma concentrations of triglycerides, total cholesterol, and high-density-lipoprotein cholesterol (HDL cholesterol) were measured in 25 healthy, middle-aged women. Bile cholesterol saturation index was negatively correlated with HDL cholesterol. It was positively correlated with plasma triglycerides and with total cholesterol minus HDL cholesterol. These findings provide a biochemical basis for a positive association in women between cholesterol gall stones and coronary artery disease.
胆固醇胆结石与冠状动脉疾病之间的关联存在争议。为了在生化水平上研究这种可能的关系，对25名健康的中年女性测量了胆汁胆固醇饱和度以及甘油三酯、总胆固醇和高密度脂蛋白胆固醇（HDL胆固醇）的血浆浓度。胆汁胆固醇饱和指数与HDL胆固醇呈负相关。它与血浆甘油三酯以及总胆固醇减去HDL胆固醇呈正相关。这些发现为女性胆固醇胆结石与冠状动脉疾病之间的正相关提供了生化依据。
