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绿原酸改善 PTSD 样症状及相关机制。

Chlorogenic Acid Improves PTSD-like Symptoms and Associated Mechanisms.

机构信息

State Key Laboratory of Trauma, Burns and Combined Injury, Daping Hospital, Army Medical University, Chongqing 400042, China.

College of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing 400054, China.

出版信息

Curr Neuropharmacol. 2021;19(12):2180-2187. doi: 10.2174/1570159X19666210111155110.

DOI:10.2174/1570159X19666210111155110
PMID:33430733
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9185768/
Abstract

Chlorogenic acid (CGA) is a kind of traditional Chinese medicine, abundant in honeysuckle and eucommia, and has a wide range of biological activities, and pharmacological effects. Previous studies have shown that CGA can regulate learning, memory, cognitive ability, coupled with improvement to anxiety, depression, and other post-traumatic stress disorder (PTSD)-like symptoms. This article explores the protective effects of CGA on neurons through its anti-apoptotic effect, inhibition of neuroinflammation and oxidative stress, which may be the mechanisms of its improvement of PTSD-like symptoms. It may provide a new therapeutic strategy for the treatment of PTSD and its comorbidities.

摘要

绿原酸（CGA）是一种中药，在金银花和杜仲中含量丰富，具有广泛的生物活性和药理作用。先前的研究表明，CGA 可以调节学习、记忆、认知能力，同时改善焦虑、抑郁和其他创伤后应激障碍（PTSD）样症状。本文通过其抗细胞凋亡作用、抑制神经炎症和氧化应激，探讨了 CGA 对神经元的保护作用，这可能是其改善 PTSD 样症状的机制。它可能为 PTSD 及其合并症的治疗提供新的治疗策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/440f/9185768/eefc37c8acd3/CN-19-2180_F3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/440f/9185768/a5b60b34fd55/CN-19-2180_F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/440f/9185768/7ba76ded5892/CN-19-2180_F2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/440f/9185768/eefc37c8acd3/CN-19-2180_F3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/440f/9185768/a5b60b34fd55/CN-19-2180_F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/440f/9185768/7ba76ded5892/CN-19-2180_F2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/440f/9185768/eefc37c8acd3/CN-19-2180_F3.jpg

相似文献

[1]
Chlorogenic Acid Improves PTSD-like Symptoms and Associated Mechanisms.

Curr Neuropharmacol. 2021

[2]
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[3]
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[4]
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[5]
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[6]
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[7]
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[8]
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[9]
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[10]
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[3]
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Plants (Basel). 2024-6-14

[4]
CGA alleviates LPS-induced inflammation and milk fat reduction in BMECs through the NF-κB signaling pathway.

Heliyon. 2024-1-21

[5]
Rowanberry-A Source of Bioactive Compounds and Their Biopharmaceutical Properties.

Plants (Basel). 2023-9-11

[6]
Chlorogenic Acid Ameliorates Post-Infectious Irritable Bowel Syndrome by Regulating Extracellular Vesicles of Gut Microbes.

Adv Sci (Weinh). 2023-10

[7]
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J Int Soc Sports Nutr. 2023-12

[8]
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Mol Neurobiol. 2023-11

[9]
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[10]
Evaluation of the Membrane Damage Mechanism of Chlorogenic Acid against and and Its Application in the Preservation of Raw Pork and Skim Milk.

Molecules. 2021-11-8

本文引用的文献

[1]
Chlorogenic Acid Potentiates the Anti-Inflammatory Activity of Curcumin in LPS-Stimulated THP-1 Cells.

Nutrients. 2020-9-4

[2]
Caffeic acid and chlorogenic acid cytotoxicity, genotoxicity and impact on global DNA methylation in human leukemic cell lines.

Genet Mol Biol. 2020-7-3

[3]
Neuroprotective Effect of Chlorogenic Acid on Mitochondrial Dysfunction-Mediated Apoptotic Death of DA Neurons in a Parkinsonian Mouse Model.

Oxid Med Cell Longev. 2020

[4]
Healthspan Enhancement by Olive Polyphenols in Wild Type and Parkinson's Models.

Int J Mol Sci. 2020-5-29

[5]
Chlorogenic Acid Alleviates Aβ-Induced Autophagy and Cognitive Impairment via the mTOR/TFEB Signaling Pathway.

Drug Des Devel Ther. 2020

[6]
Daily oral administration of chlorogenic acid prevents the experimental carrageenan-induced oxidative stress.

J Physiol Pharmacol. 2020-2

[7]
Healthspan Maintenance and Prevention of Parkinson's-like Phenotypes with Hydroxytyrosol and Oleuropein Aglycone in .

Int J Mol Sci. 2020-4-8

[8]
Neural Bases of Cognitive Impairments in Post-Traumatic Stress Disorders: A Mini-Review of Functional Magnetic Resonance Imaging Findings.

Front Psychiatry. 2020-3-17

[9]
Pharmacological action and potential targets of chlorogenic acid.

Adv Pharmacol. 2020

[10]
Protective Effects of Chlorogenic Acid on Cerebral Ischemia/Reperfusion Injury Rats by Regulating Oxidative Stress-Related Nrf2 Pathway.

Drug Des Devel Ther. 2020-1-7

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