实现极低 LDL 水平的问题现状。

The State of the Problem of Achieving Extremely Low LDL Levels.

机构信息

Petrozavodsk State University, Faculty Therapy Department, 185000 Lenin Ave., 33, Petrozavodsk, Russian Federation.

Lipidology and Lipoprotein Apheresis Center, Department of Internal Medicine III, University Hospital Carl Gustav Carus at the Technische Universtät Dresden, Fetscherstr. 74, 01307 Dresden, Germany.

出版信息

Curr Pharm Des. 2021;27(37):3841-3857. doi: 10.2174/1381612827999210111182030.

DOI:10.2174/1381612827999210111182030

PMID:33430743

Abstract

Patients who have achieved very low low-density lipoprotein CH (LDL-C) levels in clinical trials have shown the lowest cardio-vascular risk. The current clinical guidelines set such a concentration for LDL-C as < 1.4 mmol/L. However, the question of minimum permissible target values of the lipids remains unresolved. A number of experimental and clinical studies showed some unfavorable consequences of low LDL-C levels At the same time, the modern arsenal of lipid lowering drugs allows reducing LDL-C levels to extremely low values. This review presents an analysis of literature about the safety of low lipid spectrum parameters.

摘要

在临床试验中，那些 LDL-C（低密度脂蛋白胆固醇）水平达到极低值的患者表现出最低的心血管风险。目前的临床指南将 LDL-C 的浓度设定为 < 1.4 mmol/L。然而，关于脂质最低可允许目标值的问题仍然没有得到解决。许多实验和临床研究表明 LDL-C 水平较低会产生一些不利后果。与此同时，现代的降脂药物库允许将 LDL-C 水平降低到极低的值。这篇综述分析了关于低血脂谱参数安全性的文献。