中国系统性红斑狼疮治疗与研究协作组登记研究（CSTAR）十三：系统性红斑狼疮患者慢性瘢痕性脱发的患病率及危险因素

Chinese SLE Treatment and Research Group Registry (CSTAR) XIII: prevalence and risk factors for chronic scarring alopecia in patients with systemic lupus erythematosus.

作者信息

Xiang Yirong, Li Mengtao, Luo Hui, Wang Yanhong, Duan Xinwang, Zhao Cheng, Zhan Feng, Wu Zhenbiao, Li Hongbin, Yang Min, Xu Jian, Wei Wei, Wu Lijun, You Hanxiao, Qian Junyan, Yang Xiaoxi, Huang Can, Zhao Jiuliang, Wang Qian, Leng Xiaomei, Tian Xinping, Zhao Yan, Zeng Xiaofeng

机构信息

Department of Rheumatology, State Key Laboratory of Complex Severe and Rare Diseases, National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Key Laboratory of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, No. 1 Shuaifuyuan, Wangfujing Ave, Beijing, 100730, China.

Department of Rheumatology, Xiangya Hospital, Central South University, Changsha, China.

出版信息

Arthritis Res Ther. 2021 Jan 11;23(1):20. doi: 10.1186/s13075-020-02407-5.

DOI:10.1186/s13075-020-02407-5

PMID:33430947

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7802218/

Abstract

BACKGROUND

Scarring alopecia in systemic lupus erythematosus (SLE) patients caused reduced life quality and prolonged disease course. This case-control study aims to survey the prevalence of scarring alopecia during the disease course of SLE and evaluate the risk factors for scarring alopecia in Chinese SLE patients.

METHODS

SLE patients in Chinese SLE treatment and Research group (CSTAR) were recruited. Scarring alopecia was defined according to SLICC/ACR-DI which was collected during follow-up visits or via self-reported questionnaires. We collected demographic characteristics, common comorbidities, autoantibody profiles, disease activity status, major organ involvements, and treatment strategies of these patients at registry. Univariate and multivariate logistic regression analyses were used to investigate the risk factors for scarring alopecia.

RESULTS

We recruited 4792 SLE patients, and 374 (7.80%) patients had scarring alopecia. Mucocutaneous lesions (OR 2.062, p < 0.001), high SLICC/ACR-DI (OR 1.409, p < 0.001), and positive anti-Sm (OR 1.374, p = 0.029) were risk factors for scarring alopecia, while renal (OR 0.714, p = 0.028) and cardio-respiratory involvements (OR 0.347, p = 0.044), and immunosuppressant treatment (OR 0.675, p < 0.001) were significantly negative associated with it.

CONCLUSIONS

The prevalence of scarring alopecia in SLE patients is 7.80%. Active treatment strategies should be adopted to prevent scarring alopecia occurring.

摘要

背景

系统性红斑狼疮（SLE）患者的瘢痕性脱发会降低生活质量并延长病程。本病例对照研究旨在调查SLE病程中瘢痕性脱发的患病率，并评估中国SLE患者瘢痕性脱发的危险因素。

方法

招募中国SLE治疗与研究组（CSTAR）中的SLE患者。瘢痕性脱发根据SLICC/ACR-DI进行定义，该指标通过随访或自我报告问卷收集。我们收集了这些患者登记时的人口统计学特征、常见合并症、自身抗体谱、疾病活动状态、主要器官受累情况和治疗策略。采用单因素和多因素逻辑回归分析来研究瘢痕性脱发的危险因素。

结果

我们招募了4792例SLE患者，其中374例（7.80%）有瘢痕性脱发。皮肤黏膜病变（OR 2.062，p < 0.001）、高SLICC/ACR-DI（OR 1.409，p < 0.001）和抗Sm阳性（OR 1.374，p = 0.029）是瘢痕性脱发的危险因素，而肾脏受累（OR 0.714，p = 0.028）、心肺受累（OR 0.347，p = 0.044）和免疫抑制剂治疗（OR 0.675，p < 0.001）与之显著负相关。