Division of Dermatology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, 270 Rama VI Road, Ratchathewi, Bangkok, 10400, Thailand.
Am J Clin Dermatol. 2018 Oct;19(5):679-694. doi: 10.1007/s40257-018-0363-8.
Cutaneous and systemic lupus erythematosus (SLE) commonly involves the hair and scalp. Alopecia can result from direct activity of disease on the scalp or from the state of physical stress in the form of telogen effluvium. Discoid lupus erythematosus and lupus panniculitis/profundus are known to cause scarring alopecia, while accumulation of recent studies has shown that non-scarring alopecia in SLE may have different subtypes, comprising lupus erythematosus-specific and lupus erythematosus-nonspecific changes on histology. This review aims to summarize the clinical pattern, trichoscopic, histopathological, and direct immunofluorescence features of different types of alopecia in cutaneous and systemic lupus erythematosus, as well as exploring their relationship with SLE disease activity.
皮肤和系统性红斑狼疮（SLE）通常累及头皮和毛发。脱发可由头皮疾病的直接活动引起，也可由休止期脱发的身体压力状态引起。盘状红斑狼疮和狼疮性脂膜炎/深部狼疮已知可导致瘢痕性脱发，而越来越多的研究表明，SLE 的非瘢痕性脱发可能有不同的亚型，包括组织学上的狼疮特异性和狼疮非特异性改变。本文旨在总结皮肤和系统性红斑狼疮中不同类型脱发的临床特征、毛发镜、组织病理学和直接免疫荧光特征，并探讨其与 SLE 疾病活动的关系。
