Kaufman A J, Tarr R W, Holburn G E, McCurdy M, Partain C L, James A E
Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, Tennessee 37232.
Invest Radiol. 1988 Feb;23(2):93-7. doi: 10.1097/00004424-198802000-00003.
Acute mesenteric ischemic bowel disease is a common yet complex disorder with high morbidity and mortality rates predominantly caused by delayed diagnosis. We examined the role of magnetic resonance imaging (MRI) in the early detection of small bowel ischemia using the rabbit model. Surgical ligation of the appropriate arterial vascular supply to the ileum of 10 rabbits produced the ischemic compromise. The animals were imaged at different time intervals after the arterial occlusion. Multislice, T1 and T2-weighted images were obtained in axial and coronal planes. Abnormal findings of the dearterialized segment of bowel were visualized as early as 45 minutes after vascular occlusion. The findings consisted of: (1) bowel wall thickening, (2) two- to three-fold increase in signal intensity from bowel on T2-weighted images, and (3) isointensity or slightly increased signal intensity within the bowel wall on T1-weighted images. MRI appears to be a sensitive, noninvasive technique for the early detection of bowel ischemia in the rabbit animal model.
急性肠系膜缺血性肠病是一种常见但复杂的疾病，发病率和死亡率高，主要原因是诊断延迟。我们使用兔模型研究了磁共振成像（MRI）在小肠缺血早期检测中的作用。对10只兔子的回肠进行适当动脉血管供应的手术结扎，造成缺血损伤。在动脉闭塞后的不同时间间隔对动物进行成像。在轴向和冠状平面上获得多层T1加权和T2加权图像。早在血管闭塞后45分钟就可观察到去动脉化肠段的异常表现。这些表现包括：（1）肠壁增厚；（2）T2加权图像上肠的信号强度增加两到三倍；（3）T1加权图像上肠壁内等信号或信号强度略有增加。在兔动物模型中，MRI似乎是一种用于早期检测肠缺血的敏感、非侵入性技术。
