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年轻女性多发性硬结节:罕见的结节病表现。

Multiple firm nodules in a young woman: an unusual presentation of sarcoidosis.

机构信息

Department of Dermatology, Tehran University of Medical Sciences, Tehran, Iran (the Islamic Republic of)

Department of Pathology, Tehran University of Medical Sciences, Tehran, Iran (the Islamic Republic of).

出版信息

BMJ Case Rep. 2021 Jan 11;14(1):e237264. doi: 10.1136/bcr-2020-237264.

Abstract

A 27-year-old woman presented to the dermatology department with a 1-year history of multiple asymptomatic violaceous lesions on her upper and lower extremities, trunk and abdomen. The lesions were firm on palpation. She had no other associated symptoms and the rest of the examination was unremarkable. An incisional biopsy showed multiple confluent granulomas composed of histiocytes devoid of necrosis surrounded by a rim of lymphocytes extending to the subcutaneous fat consistent with the diagnosis of subcutaneous sarcoidosis. The serum ACE assay was elevated at 134 IU/L. Other blood tests including complete blood count, renal and liver function tests, serum calcium and phosphate were within normal ranges and chest X-ray was unremarkable. Complete remission was achieved with an intralesional triamcinolone injection (10 mg/mL) for a few sessions. Subcutaneous sarcoidosis is a rare variation and its diagnosis requires a high index of suspicion.

摘要

一位 27 岁女性因上、下肢、躯干和腹部出现多个无症状的紫红色皮损 1 年而就诊于皮肤科。皮损触诊坚实。患者无其他相关症状,其余检查未见异常。切开活检显示多个融合性肉芽肿,由组织细胞组成,无坏死,周围有淋巴细胞环延伸至皮下脂肪,符合皮下结节病的诊断。血清 ACE 测定升高至 134IU/L。其他血液检查包括全血细胞计数、肾功能和肝功能检查、血清钙和磷均在正常范围内,胸部 X 线检查未见异常。皮损内注射曲安奈德(10mg/ml)数次后达到完全缓解。皮下结节病是一种罕见的变异,其诊断需要高度怀疑。

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