Glaze M B, Crawford M A, Nachreiner R F, Casey H W, Nafe L A, Kearney M T
Department of Veterinary Clinical Sciences, Louisiana State University, Baton Rouge 70803.
J Am Vet Med Assoc. 1988 Jan 1;192(1):73-5.
Degenerative myopathy suggestive of glucocorticoid-induced myopathy was diagnosed in a 10-year-old female Poodle X Pekingese dog with a history of progressive lameness. Electromyography revealed bizarre high-frequency discharges. Evidence of adrenal suppression was obtained in response to exogenous ACTH. The predominant source of corticosteroid was an ophthalmic preparation used in the management of keratoconjunctivitis sicca. Considering the apparent adverse effects of the corticosteroid in this case, a study was undertaken to determine the systemic effects, if any, induced by long-term ophthalmic administration of 0.1% dexamethasone suspension in healthy adult dogs. Dogs in one group (n = 5) were treated 4 times daily for 8 weeks, and dogs in another group (n = 5) were treated 4 times daily for 16 weeks. All dogs remained healthy throughout the study, but dexamethasone-treated dogs developed marked adrenal suppression, beginning the second week of treatment and intensifying throughout the treatment period. Histopathologic changes in the liver of dexamethasone-treated dogs included scattered foci of vacuolated hepatocytes, increased hepatocytic glycogen content, and ballooning degeneration of hepatocytes. Muscle specimens were histologically, histochemically, and electromyographically normal.
一只患有进行性跛行病史的10岁贵宾犬与北京犬杂交母犬被诊断为疑似糖皮质激素诱导性肌病的退行性肌病。肌电图显示出奇异的高频放电。对外源性促肾上腺皮质激素的反应获得了肾上腺抑制的证据。皮质类固醇的主要来源是用于治疗干眼症的眼科制剂。考虑到该病例中皮质类固醇明显的不良反应，开展了一项研究以确定在健康成年犬中长期眼部给予0.1%地塞米松混悬液是否会产生全身影响（若有）。一组犬（n = 5）每日接受4次治疗，持续8周，另一组犬（n = 5）每日接受4次治疗，持续16周。在整个研究过程中所有犬均保持健康，但地塞米松治疗的犬从治疗第二周开始出现明显的肾上腺抑制，并在整个治疗期间加重。地塞米松治疗犬肝脏的组织病理学变化包括散在的空泡化肝细胞灶、肝细胞糖原含量增加以及肝细胞气球样变性。肌肉标本在组织学、组织化学和肌电图方面均正常。
