Department of Experimental Dentistry and Prophylaxis, Medical College, Jagiellonian University in Krakow.
ORTODENT, Specialist Orthodontic Private Practice in Grudziadz.
Eur J Orthod. 2021 Dec 1;43(6):631-638. doi: 10.1093/ejo/cjaa083.
BACKGROUND/OBJECTIVES: The aim of the study was to compare the stability of orthodontic treatment in cancer survivors who had been treated with cytotoxic drugs with a generally healthy control group.
MATERIALS/METHODS: The study included 52 cancer survivors treated orthodontically and 52 healthy control subjects matched for age, gender, and malocclusion. The weighted Peer Assessment Rating (w-PAR) index, the Index of Complexity, Outcome and Need (ICON) were assessed before treatment, after the treatment, and at the 3-year follow-up. Patients Satisfaction Score was assessed after the treatment and at the 3-year follow-up. A repeated analysis of variance test was used to check the statistical significance between the scores.
Ideal occlusion was achieved in all patients. The mean w-PAR and ICON values were significantly reduced in both groups after the end of the orthodontic treatment with no significant differences between the groups regarding the obtained results. However, after the 3-year follow-up, only the cancer survivors' group presented statistically significant (P < 0.001) increase of the w-PAR and ICON values comparing to the values obtained at the end of the treatment. There was no significant change in Patients' Satisfaction Score within 3 years after treatment.
The limited size of the study sample as well as different types of oncological diagnoses could have had an impact on the final results of the study.
CONCLUSIONS/IMPLICATIONS: Previous cytotoxic drug treatment significantly decreases the stability of orthodontic treatment among the cancer survivors, particularly within first 12 months after the end of the treatment.
背景/目的：本研究旨在比较接受细胞毒性药物治疗的癌症幸存者与一般健康对照组在正畸治疗中的稳定性。
材料/方法：该研究纳入了 52 名接受正畸治疗的癌症幸存者和 52 名年龄、性别和错畸形匹配的健康对照组。在治疗前、治疗后和 3 年随访时，使用加权同伴评估评分（w-PAR）指数和复杂性、结局和需求指数（ICON）进行评估。在治疗后和 3 年随访时，使用患者满意度评分进行评估。使用重复方差分析检验来检查分数之间的统计学显著性。
所有患者均达到理想的咬合。两组在正畸治疗结束后，w-PAR 和 ICON 平均值均显著降低，两组的结果无显著差异。然而，在 3 年随访时，仅癌症幸存者组的 w-PAR 和 ICON 值与治疗结束时相比显著增加（P<0.001）。治疗后 3 年内，患者满意度评分无显著变化。
研究样本量有限以及不同类型的肿瘤诊断可能对研究的最终结果产生影响。
结论/意义：先前的细胞毒性药物治疗显著降低了癌症幸存者正畸治疗的稳定性，特别是在治疗结束后的 12 个月内。
