Lawson D H, Davidson J F, Jick H
Br Med J. 1977 Sep 17;2(6089):729-30. doi: 10.1136/bmj.2.6089.729.
We conducted a case-control study to test the hypothesis that women smokers who use oral contraceptives have an increased risk of developing venous thrombosis. Patients and controls were drawn from two sets of hospital patients already included in the Boston Collaborative Drug Surveillance Programme. Sixty patients with uncomplicated thromboembolism were matched with 180 controls with other diagnoses; all were premenopausal women taking oral contraceptives. Patients with conditions that might predispose to thromboembolism or be related to smoking were excluded. We found no association between smoking habits and thromboembolism. Similarly, we found no association between thromboembolism, smoking, and duration of oral contraceptive use. Thus we conclude that differences in fibrinolytic activity between smokers and non-smokers are not major factors in the aetiology of uncomplicated thromboembolism in women using oral contraceptives.
我们进行了一项病例对照研究，以检验使用口服避孕药的女性吸烟者发生静脉血栓形成风险增加这一假设。患者和对照来自波士顿药物监测协作计划中已纳入的两组医院患者。60例无并发症的血栓栓塞患者与180例患有其他疾病的对照进行匹配；所有患者均为服用口服避孕药的绝经前女性。排除了可能易患血栓栓塞或与吸烟有关的疾病患者。我们发现吸烟习惯与血栓栓塞之间无关联。同样，我们发现血栓栓塞、吸烟与口服避孕药使用时长之间也无关联。因此，我们得出结论，吸烟者与非吸烟者之间纤溶活性的差异并非使用口服避孕药的女性发生无并发症血栓栓塞病因中的主要因素。
