Department of Cardiology, University of Medicine and Pharmacy, Craiova 200349, Romania.
Department of Physiology, University of Medicine and Pharmacy, Craiova 200349, Romania.
Asian J Androl. 2021 Jul-Aug;23(4):348-356. doi: 10.4103/aja.aja_80_20.
Testosterone exerts an important regulation of cardiovascular function through genomic and nongenomic pathways. It produces several changes in cardiomyocytes, the main actor of cardiomyopathies, which are characterized by pathological remodeling, eventually leading to heart failure. Testosterone is involved in contractility, in the energy metabolism of myocardial cells, apoptosis, and the remodeling process. In myocarditis, testosterone directly promotes the type of inflammation that leads to fibrosis, and influences viremia with virus localization. At the same time, testosterone exerts cardioprotective effects that have been observed in different studies. There is increasing evidence that low endogenous levels of testosterone have a negative impact in some cardiomyopathies and a protective impact in others. This review focuses on the interrelationships between testosterone and cardiomyopathies and heart failure.
睾酮通过基因组和非基因组途径对心血管功能发挥重要调节作用。它可使心肌病的主要作用细胞——心肌细胞产生多种变化，其特征是病理性重构，最终导致心力衰竭。睾酮参与心肌细胞的收缩、能量代谢、细胞凋亡和重构过程。在心肌炎中，睾酮直接促进导致纤维化的炎症类型，并影响病毒定位的病毒血症。同时，睾酮发挥了不同研究中观察到的心脏保护作用。越来越多的证据表明，内源性睾酮水平低对某些心肌病有负面影响，而对另一些则有保护作用。本综述重点关注睾酮与心肌病和心力衰竭之间的相互关系。
