细胞分裂：染色质动力学塑造昆虫全着丝粒

Cell Division: Chromatin Dynamics Shape Insect Holocentromeres.

机构信息

Instituto de Investigação e Inovação em Saúde - i3S, Universidade do Porto, 4200-135 Porto, Portugal.

出版信息

Curr Biol. 2021 Jan 11;31(1):R34-R37. doi: 10.1016/j.cub.2020.10.049.

DOI:10.1016/j.cub.2020.10.049

Abstract

Centromeres, the chromosomal loci that ensure chromosome segregation by directing kinetochore assembly, are typically marked by the histone CENP-A. A study in CENP-A-deficient insects finds that virtually any chromosomal region with low nucleosome turnover can assemble kinetochores, highlighting the extraordinary plasticity of holocentromeres.

摘要

着丝粒是确保染色体分离的染色体位点，通过指导动粒组装来实现，通常由组蛋白 CENP-A 标记。一项在 CENP-A 缺陷的昆虫中的研究发现，几乎任何具有低核小体周转率的染色体区域都可以组装动粒，这突出了全着丝粒的非凡可塑性。