Parker K J, Tuthill T A, Baggs R B
Rochester Center for Biomedical Ultrasound, University of Rochester, New York 14627.
J Acoust Soc Am. 1988 Jan;83(1):374-8. doi: 10.1121/1.396528.
The excess ultrasonic attenuation caused by adding glycogen and inorganic phosphate to liver homogenates has been studied to determine the underlying differences between attenuation coefficients of normal and diffusely diseased livers. Results show that glycogen has a higher than average specific absorption coefficient compared to other large molecular weight biomolecules. Since the glycogen content of liver can vary from 1%-10% of wet weight, this compound may have a major time-varying effect on the liver ultrasonic attenuation coefficient, even in normal subjects. In contrast, the excess attenuation of liver homogenate resulting from addition of inorganic phosphate was not significant at presumed physiological levels. The implications of these findings are discussed relative to tissue characterization efforts based on in vivo measurements of ultrasonic attenuation coefficients of liver.
通过向肝脏匀浆中添加糖原和无机磷酸盐来研究由此产生的超声衰减过量情况，以确定正常肝脏和弥漫性病变肝脏衰减系数之间的潜在差异。结果表明，与其他大分子生物分子相比，糖原具有高于平均水平的比吸收系数。由于肝脏中糖原含量可在湿重的1%-10%之间变化，即使在正常受试者中，这种化合物也可能对肝脏超声衰减系数产生主要的随时间变化的影响。相比之下，在假定的生理水平下，添加无机磷酸盐导致的肝脏匀浆过量衰减并不显著。相对于基于肝脏超声衰减系数体内测量的组织表征研究，讨论了这些发现的意义。
