Liu Yanping, Zhang Xuwu, Luo Liyao, Li Lei, He Yuchu, An Jing, Gao Dawei
Applying Chemistry Key Lab of Hebei Province, Department of Bioengineer, Yanshan University, No. 438 Hebei Street, Qinhuangdao 066004, China.
Hebei Province Asparagus Industry Technology Research Institute, Qinhuangdao 066004, China.
ACS Biomater Sci Eng. 2018 Aug 13;4(8):2911-2921. doi: 10.1021/acsbiomaterials.8b00766. Epub 2018 Jul 31.
Synergistic cancer therapy through the combination of chemotherapy with photothermal therapy has been gained more and more insights. Bimetallic nanostructures with near-infrared (NIR) plasmonic responses are considered prime candidates based on their superior photothermal conversion properties. Herein, novel poly branched Au-Pd bimetallic-nanoflowers-coated betulinic acid liposomes (BA-Lips@Pd@Au NFs) were designed and developed. The as-prepared BA-Lips@Pd@Au NFs with optimal size (144.4 nm) possessed good photostability under NIR-irradiation, high photothermal conversion efficiency (64.6%), and good biocompatibility. Moreover, the hyperthermia of drug delivery induced by NIR-irradiation dramatically improved the cell uptake of nanocapsules and enhanced the chemotherapeutic efficacy of tumor. Upon illumination by NIR light, the BA-Lips@Pd@Au NFs exhibited prominent synergetic effects of chemo-photothermal therapy with a tumor inhibition ratio (91.7%), which was higher than that of chemotherapy or photothermal therapy alone. Therefore, this rational design of nanocapsule with stimuli-responsive capability showed a versatile strategy to provide smart nanocapsule paradigms for cancer therapy.
通过化疗与光热疗法相结合的协同癌症治疗已获得越来越多的认识。具有近红外（NIR）等离子体响应的双金属纳米结构因其优异的光热转换特性而被认为是主要候选者。在此，设计并开发了新型的多分支金-钯双金属纳米花包覆桦木酸脂质体（BA-Lips@Pd@Au NFs）。所制备的具有最佳尺寸（144.4 nm）的BA-Lips@Pd@Au NFs在近红外辐射下具有良好的光稳定性、高光热转换效率（64.6%）和良好的生物相容性。此外，近红外辐射诱导的药物递送热疗显著提高了纳米胶囊的细胞摄取，并增强了肿瘤的化疗疗效。在近红外光照射下，BA-Lips@Pd@Au NFs表现出显著的化疗-光热疗法协同效应，肿瘤抑制率为91.7%，高于单独的化疗或光热疗法。因此，这种具有刺激响应能力的纳米胶囊的合理设计展示了一种通用策略，可为癌症治疗提供智能纳米胶囊范例。
